Homopiperazine, identified by its CAS number 505-66-8, is a compound of significant interest in both the pharmaceutical and chemical industries. Its fundamental importance stems from its unique structure as a seven-membered heterocyclic diamine and its resulting versatile chemical properties. Understanding its synthesis and physical characteristics is key to appreciating its wide-ranging applications.

The synthesis of Homopiperazine is often achieved through multi-step chemical processes. A common and economically viable route involves using readily available ethylenediamine as a starting material. This process typically includes steps such as sulfonylation, cyclization, and de-sulfonylation. The yield from such methods can be substantial, making it amenable to large-scale industrial production. For instance, the use of phase transfer catalysts during the sulfonylation step can significantly enhance product yield, with optimized reaction systems like NaH/DMF in the cyclization phase allowing for milder reaction conditions. The choice of raw materials and reaction parameters plays a crucial role in the efficiency and purity of the final Homopiperazine product, highlighting the importance of precise homopiperazine synthesis applications.

Chemically, Homopiperazine presents as a white to light yellow crystalline mass. Its physical properties include a melting point typically ranging from 38-40°C and a boiling point around 169°C. It is soluble in water and exhibits sensitivity to air and moisture, necessitating careful storage in closed containers in cool, dry conditions. The compound's molecular formula is C5H12N2, with a molecular weight of approximately 100.16 g/mol. Its pKa value is around 11.02, indicating its basic nature due to the presence of two nitrogen atoms.

The structural configuration of Homopiperazine, with its two nitrogen atoms within a seven-membered ring, allows for various chemical modifications and interactions. This inherent reactivity is what makes it such a valuable intermediate in organic synthesis. Researchers often leverage these properties to create derivatives with specific biological activities or material functionalities. For example, substituting hydrogen atoms on the nitrogen can lead to compounds used as wetting agents, emulsifying agents, or detergents. This chemical versatility is central to its role as a key component in advancing pharmaceutical intermediate homopiperazine applications.

The meticulous study of CAS 505-66-8 chemical uses reveals its broad applicability. From its critical function in synthesizing life-saving drugs to its use in industrial processes, the properties of Homopiperazine are central to its value. Companies like NINGBO INNO PHARMCHEM CO.,LTD. focus on optimizing synthesis routes and ensuring product quality to meet the diverse demands of researchers and manufacturers who rely on this essential chemical intermediate.

In summary, Homopiperazine is a compound defined by its accessible synthesis pathways and useful chemical properties. Its crystalline appearance, solubility, and reactivity make it a cornerstone for innovation in pharmaceuticals and beyond. Continued research into its synthesis and applications promises further advancements in various scientific and industrial fields.