The efficient synthesis and reliable sourcing of chemical intermediates are foundational to the success of numerous industries, from pharmaceuticals to agrochemicals. 5-Chloro-1-Indanone (CAS: 42348-86-7) is a prime example of such a critical compound, playing a pivotal role in various advanced chemical processes. This article explores its synthesis routes and guides potential buyers on identifying reputable global suppliers.

Synthesis Pathways for 5-Chloro-1-Indanone

The preparation of 5-Chloro-1-Indanone typically involves a Friedel-Crafts acylation reaction. A common route starts with 3-chlorobenzaldehyde, which is reacted with propionic acid to yield 3-chlorophenylpropionic acid. This precursor is then cyclized, often using reagents like thionyl chloride followed by an aluminum chloride-catalyzed cyclization, to form the target 5-Chloro-1-Indanone. Advancements in synthesis aim to improve yield, reduce by-products, and employ greener catalysts, such as mixed molten salts and heteropolyacids, to achieve higher efficiency and minimize environmental impact. For instance, some modern methods focus on controlling reaction temperatures and using specific catalysts to prevent issues like pipeline blockage and tar formation, thereby increasing yield to up to 85%.

Key Applications Driving Demand

The demand for 5-Chloro-1-Indanone is primarily fueled by its use as:

  • An Intermediate for Indoxacarb: This is a major application, as it's a key component in producing the widely used insecticide Indoxacarb.
  • A Pharmaceutical Intermediate: It is utilized in the synthesis of various medicinal compounds, including potential anticonvulsants, anticholinergics, and anti-cancer agents.
  • A Building Block in Organic Synthesis: Its versatile structure makes it valuable for creating complex organic molecules for R&D and specialized industrial applications.

Finding Reliable 5-Chloro-1-Indanone Suppliers

When looking to buy 5-Chloro-1-Indanone, prospective buyers should focus on identifying reliable manufacturers and suppliers. Key factors to consider:

  • Purity and Quality Control: Always verify the purity specifications (e.g., ≥99% by HPLC) and request comprehensive Certificates of Analysis (CoA).
  • Production Scale: Ensure the supplier can cater to both research-scale and industrial-scale quantities.
  • Geographic Reach: Identify suppliers with a global presence or strong export capabilities, particularly from regions known for chemical manufacturing expertise, such as China.
  • Pricing and Value Proposition: Obtaining multiple quotes for the price of 5-Chloro-1-Indanone, considering purity and delivery terms, is essential for cost-effective procurement.
  • Regulatory Adherence: Confirm that suppliers comply with safety and environmental regulations.

As a critical intermediate, 5-Chloro-1-Indanone plays a significant role in advancing chemical industries. By understanding its synthesis and carefully selecting suppliers, businesses can ensure access to this vital compound, supporting their product development and manufacturing goals. We are a dedicated supplier committed to providing high-quality 5-Chloro-1-Indanone. Contact us to discuss your procurement needs and receive competitive pricing.