For chemists engaged in organic synthesis and pharmaceutical development, understanding the synthesis routes and applications of key chemical intermediates is fundamental. 6-Chloro-5-(2-chloroethyl)oxindole, identified by its CAS number 118289-55-7, is a compound of significant interest, particularly for its role as a precursor in the synthesis of vital pharmaceutical products. This article explores its chemical properties, common synthesis methods, and its market relevance for manufacturers and researchers.

Chemical Profile and Synthesis Pathways

6-Chloro-5-(2-chloroethyl)oxindole, with the molecular formula C10H9Cl2NO and a molecular weight of 230.09 g/mol, typically appears as a pale pink solid. Its synthesis often involves multi-step processes starting from more basic chemical building blocks. Common routes include reactions involving the chlorination of precursor compounds, such as those with a hydroxyethyl group, or cyclization reactions to form the oxindole ring structure. For instance, reactions employing reagents like triphenylphosphine or thionyl chloride, followed by reduction and chlorination steps, are documented methods. The efficiency and yield of these synthesis pathways are crucial for providing a cost-effective and reliable supply of the intermediate.

Key Applications in the Pharmaceutical Industry

The primary and most well-known application of 6-Chloro-5-(2-chloroethyl)oxindole is its critical role as an intermediate in the production of Ziprasidone. Ziprasidone is an atypical antipsychotic used in the treatment of schizophrenia and bipolar disorder. The synthesis of Ziprasidone involves several chemical steps, with this oxindole derivative serving as a key building block that provides the core structure for the final active pharmaceutical ingredient (API). Beyond this established use, researchers are continuously exploring the potential of this intermediate in creating novel chemical entities with therapeutic applications, making it a compound of ongoing research interest.

Sourcing and Market Availability

For pharmaceutical manufacturers and research institutions, securing a consistent and high-quality supply of 6-Chloro-5-(2-chloroethyl)oxindole is essential. China has emerged as a primary source for such chemical intermediates, offering a broad spectrum of suppliers with varying capacities and quality standards. When looking to buy this compound, it is advisable to engage with experienced manufacturers who can guarantee purity, provide comprehensive analytical documentation (such as CoA), and offer competitive pricing, especially for bulk orders. Understanding the supply chain and establishing relationships with reputable suppliers can ensure timely delivery and mitigate risks associated with material sourcing.

Factors Influencing Price and Quality

The market price for 6-Chloro-5-(2-chloroethyl)oxindole is influenced by several factors, including the cost of raw materials, manufacturing processes, purity requirements, and global demand. High-purity grades, suitable for pharmaceutical synthesis, typically command higher prices. Procurement specialists should actively seek quotes from multiple Chinese manufacturers and compare their offerings based on quality specifications, lead times, and overall value.

In summary, 6-Chloro-5-(2-chloroethyl)oxindole is a vital intermediate with significant applications in pharmaceutical synthesis, particularly for the production of Ziprasidone. Its synthesis involves well-established chemical routes, and its market availability is strong, with Chinese manufacturers being key suppliers. For companies needing this compound, a strategic approach to sourcing, focusing on quality and supplier reliability, is essential for success.