In the realm of organic chemistry, intermediates that offer versatile reactivity and structural utility are highly prized. 1-Methylimidazole-4-carboxylic Acid (CAS: 41716-18-1) is one such compound, serving as a valuable precursor in a multitude of synthetic endeavors. This article delves into its synthesis, properties, and key applications, providing essential knowledge for chemists and procurement professionals looking to acquire this important chemical.

Synthetic Pathways to 1-Methylimidazole-4-carboxylic Acid

While specific industrial synthesis routes can be proprietary, the preparation of 1-Methylimidazole-4-carboxylic Acid generally involves modifications of imidazole rings. Common strategies might include methylation of imidazole-4-carboxylic acid or the synthesis of the imidazole ring with the desired substituents already in place. For instance, reactions involving glyoxal derivatives, amines, and carboxylic acid precursors can be employed. Understanding these pathways helps appreciate the manufacturing expertise required by suppliers who produce this compound with high purity (95%min) and consistent quality.

Key Properties and Handling

1-Methylimidazole-4-carboxylic Acid has the chemical formula C5H6N2O2 and a molecular weight of 126.11300. It typically presents as a white to tawny solid powder, a form that facilitates straightforward handling and storage. Its stability under standard conditions is a significant advantage for researchers and manufacturers alike. The compound's melting point of 245 °C suggests a relatively stable crystalline structure. When considering a purchase, always confirm these details with your supplier to ensure they meet your operational requirements.

Applications Across Chemical Disciplines

The utility of 1-Methylimidazole-4-carboxylic Acid spans several critical areas of chemistry:

  • Pharmaceutical Intermediates: It serves as a crucial building block in the synthesis of various pharmaceutical agents. Its imidazole core is a prevalent feature in many drugs targeting different therapeutic areas.
  • Fine Chemical Synthesis: The carboxylic acid functionality allows for reactions like esterification, amidation, and salt formation, while the imidazole ring can participate in metal-catalyzed cross-coupling reactions or act as a ligand.
  • Materials Science: Derivatives of imidazole compounds are sometimes explored for their potential in creating novel functional materials, including coordination polymers or specialty polymers.
  • Research and Development: Its availability makes it a convenient starting material for exploring new chemical reactions and discovering novel compounds with potential biological activity.

Procurement and Supplier Excellence

For those looking to buy 1-Methylimidazole-4-carboxylic Acid, selecting a reliable manufacturer and supplier is paramount. Companies that offer transparent specifications, consistent quality, and competitive pricing are ideal partners. When sourcing from China, for example, look for suppliers with a strong emphasis on quality control and customer service. Obtaining quotes and samples is a standard practice to ensure the material meets your exact needs for your synthesis projects. Investing time in finding the right manufacturer for this key intermediate will pay dividends in your project's success.

In essence, 1-Methylimidazole-4-carboxylic Acid is a compound of significant synthetic value. Understanding its synthesis, properties, and broad applications allows chemists and procurement professionals to leverage its potential effectively, ensuring efficient and successful chemical production and research.