In the realm of chemical research and development (R&D), the availability of versatile intermediates is crucial for innovation. 2-Cyanoisonicotinohydrazide (CAS 135048-32-7) is one such compound that has garnered significant attention due to its unique structural features and broad utility in synthetic chemistry. Understanding its preparation methods and applications provides valuable insights for R&D professionals seeking to expand their synthetic capabilities.

Synthetic Pathways to 2-Cyanoisonicotinohydrazide

The synthesis of 2-Cyanoisonicotinohydrazide typically involves reactions utilizing readily available precursors. Common routes often start from derivatives of isonicotinic acid. For instance, esterification of 2-cyanopyridine-4-carboxylic acid to form methyl 2-cyanopyridine-4-carboxylate, followed by a reaction with hydrazine hydrate, yields the desired product. Alternatively, direct reaction of 2-cyanopyridine-4-carboxylic acid with hydrazine can also be employed under specific conditions. Researchers in the field constantly explore and optimize these synthetic routes to improve yields, reduce reaction times, and enhance purity, making it more accessible for R&D use. When you need to buy this compound for your lab, ensuring the supplier offers consistent quality from these optimized processes is key.

Applications in Advanced Chemical Synthesis

The distinct functional groups present in 2-Cyanoisonicotinohydrazide make it a valuable synthon in organic chemistry. The hydrazide moiety can readily undergo condensation reactions, forming hydrazones, which are important intermediates for various heterocyclic ring formations, including pyrazoles, triazoles, and oxadiazoles. The cyano group can be further functionalized or remain as a point of electronic modification on the pyridine ring. This versatility makes it a sought-after building block for medicinal chemists and material scientists.

For R&D departments, having a reliable supplier for 2-Cyanoisonicotinohydrazide ensures that experimental pipelines remain active. The ability to source this compound in research-grade quantities, with documented purity, allows for reproducible experimental outcomes. Furthermore, exploring its use in novel reaction cascades or as a ligand in coordination chemistry offers avenues for cutting-edge research. As you plan your next research project, consider how this intermediate could unlock new possibilities. Engaging with a manufacturer who can supply this versatile molecule is the first step towards innovation.