The journey from raw materials to life-saving pharmaceuticals is complex, involving precise chemical transformations. For the synthesis of Vorinostat, a significant histone deacetylase inhibitor, Suberic Acid Monomethyl Ester (CAS: 3946-32-5) emerges as a foundational intermediate. This article explores its significance in Vorinostat production and the considerations for sourcing this chemical.

Suberic Acid Monomethyl Ester, chemically known as 8-Methoxy-8-oxooctanoic acid, is characterized by its distinct physical properties: appearing as a white crystal or a colorless liquid, with a melting point of 17-19°C. Its molecular formula, C9H16O4, and molecular weight of 188.22100 underscore its role as a well-defined organic compound. These attributes are crucial for R&D scientists and process chemists aiming to optimize synthetic routes.

The primary pathway involving Suberic Acid Monomethyl Ester leads to the formation of Vorinostat, also known as suberoylanilide hydroxamic acid (SAHA). Vorinostat's therapeutic application in oncology, particularly for cutaneous T-cell lymphoma, places immense importance on the purity and consistent supply of its precursors. Therefore, when a company decides to buy Suberic Acid Monomethyl Ester, they are not just purchasing a chemical; they are securing a vital component for a critical pharmaceutical product.

Sourcing this intermediate requires careful selection of a Suberic Acid Monomethyl Ester manufacturer. A reliable manufacturer will guarantee an assay of ≥98.0%, ensuring that downstream reactions proceed efficiently and yield a high-quality final product. Many suppliers offer this compound in 25 kg drums, but flexible packaging solutions are often available to meet diverse industrial needs. For businesses looking to purchase Monomethyl Suberate, understanding the supplier's manufacturing capabilities and quality control processes is paramount.

The competitive landscape for pharmaceutical intermediates means that understanding the 8-Methoxy-8-oxooctanoic acid price is a key part of procurement. Seeking quotes from established chemical suppliers in regions like China can offer cost advantages without compromising on quality, provided rigorous due diligence is performed. Moreover, for academic or early-stage research, identifying a supplier that offers smaller quantities of this chemical for R&D purposes is beneficial.

In essence, the role of Suberic Acid Monomethyl Ester in the synthesis of Vorinostat is indispensable. Pharmaceutical manufacturers and researchers alike must prioritize sourcing from trusted partners who can provide this intermediate with guaranteed purity and a stable supply. This focus on quality and reliability is fundamental to advancing drug development and ensuring patient safety.