Tanshinone IIA, a prominent diterpenoid isolated from the traditional Chinese herb Salvia miltiorrhiza, has emerged as a compound of significant interest in the pharmaceutical and oncology research sectors. With its CAS number 568-72-9, this natural product offers a compelling profile of biological activities, primarily its potent anticancer effects, making it a valuable pharmaceutical intermediate. As researchers and manufacturers seek reliable sources for high-quality compounds, understanding the properties and applications of Tanshinone IIA is paramount.

The multifaceted nature of Tanshinone IIA's action against cancer is a key reason for its prominence. Extensive studies have demonstrated its efficacy across a wide spectrum of cancer types, including leukemia, lung cancer, hepatocellular carcinoma, gastric carcinoma, colorectal cancer, glioma, osteosarcoma, cervical cancer, ovarian cancer, breast cancer, and prostate cancer. This broad-spectrum activity is attributed to its ability to interfere with critical cellular processes essential for cancer cell survival and proliferation.

One of the primary mechanisms through which Tanshinone IIA exerts its therapeutic effects is by inducing apoptosis, the programmed cell death, in cancer cells. It achieves this by modulating key apoptotic pathways and proteins. Furthermore, it plays a crucial role in regulating the cell cycle, effectively halting the uncontrolled division characteristic of malignant cells. Research has also pinpointed its influence on vital signaling pathways, such as the PI3K/Akt/mTOR and Ras/MAPK pathways, which are frequently dysregulated in various cancers and drive tumor growth, survival, and metastasis.

Beyond its direct cytotoxic effects, Tanshinone IIA has shown potential for synergistic activity when combined with other therapeutic agents, including Hsp90 inhibitors. This synergistic action can enhance overall treatment efficacy and potentially overcome resistance mechanisms, opening new avenues for combination therapy strategies in cancer treatment. The natural origin of Tanshinone IIA also presents an attractive profile, often associated with fewer side effects compared to synthetic compounds, though understanding its pharmacokinetic properties and potential adverse reactions is crucial for clinical translation.

For pharmaceutical companies and research institutions, sourcing high-purity Tanshinone IIA is essential for reliable experimental results and effective drug development. As a leading manufacturer and supplier, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing premium-grade Tanshinone IIA. Our reliable supply chain and stringent quality control ensure that you receive a product that meets the demanding standards of pharmaceutical research. If you are looking to buy Tanshinone IIA or require a trusted supplier for your anticancer research, we invite you to connect with us for competitive pricing and sample availability.