The intricate mechanisms governing cellular health often hinge on the delicate balance of protein ubiquitination and deubiquitination. Ubiquitin C-terminal Hydrolase L3 (UCH-L3), a key enzyme in the deubiquitination process, plays a vital role in maintaining protein homeostasis. Dysregulation of UCH-L3 has been implicated in a spectrum of human diseases, including neurological disorders and certain cancers, making it a significant target for therapeutic intervention. Consequently, potent and selective inhibitors of UCH-L3 are highly sought after by researchers in the biomedical field.

4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione, commonly known as TCID, emerges as a powerful tool in this context. It is a cell-permeable small molecule that specifically inhibits UCH-L3, boasting an IC50 of 0.6 µM. Crucially, TCID demonstrates a high degree of selectivity, being over 125 times more selective for UCH-L3 than for UCH-L1. This specificity is essential for isolating the cellular effects attributable to UCH-L3 activity, enabling more accurate research findings. Researchers looking to buy TCID can leverage its properties to investigate fundamental biological processes and explore novel therapeutic avenues.

The utility of TCID extends to its application in drug development pipelines. By acting as a chemical probe, it allows scientists to understand the consequences of UCH-L3 inhibition in disease models. This can lead to the identification of new drug targets or the validation of existing ones. When seeking to purchase TCID, it is vital to partner with a reliable TCID manufacturer that ensures product quality and provides timely delivery. Companies in China are increasingly recognized for their capacity to synthesize and supply high-quality research chemicals like TCID, often at competitive price points, supporting global research efforts.

For professionals in the pharmaceutical and biotechnology sectors, securing a consistent supply of high-purity TCID is critical for their research programs. Engaging with a trusted TCID supplier that can offer not only quality products but also competitive pricing for bulk orders is a strategic advantage. The ability to effectively modulate UCH-L3 activity through compounds like TCID opens up new avenues for understanding disease mechanisms and developing targeted therapies. Therefore, prioritizing quality and accessibility when sourcing this important research chemical is key to driving innovation in drug discovery and development.