For R&D scientists and procurement specialists working with specialized chemical intermediates, understanding the detailed technical specifications and proper handling procedures is crucial. Boc-L-Aspartic Acid 4-tert-butyl Ester (CAS 1676-90-0) is one such compound whose precise characteristics are vital for its successful application in synthesis.

Key Technical Specifications for CAS 1676-90-0

As a high-value intermediate, Boc-L-Aspartic Acid 4-tert-butyl Ester is characterized by several key parameters:

  • Chemical Name: N-[(1,1-dimethylethoxy)carbonyl]-L-Aspartic acid, 4-(1,1-dimethylethyl) ester
  • Synonyms: Boc-L-Aspartic Acid 4-tert-butyl ester, Boc-Asp(OtBu)-OH, N-Boc-L-aspartic acid beta-t-butyl ester
  • CAS Number: 1676-90-0
  • Molecular Formula: C13H23NO6
  • Molecular Weight: Approximately 289.32 g/mol
  • Purity: Typically specified as ≥98.0% or ≥99.0% (often determined by HPLC). High purity is essential for its intended applications in pharmaceutical and peptide synthesis.
  • Appearance: This compound can present as a white to off-white powder or, in some conditions or purifications, may be described as a liquid.
  • Melting Point: When in solid form, a typical melting point range is around 64-67°C.
  • Optical Rotation: The specific optical rotation is an important parameter for chiral compounds, often measured at a specific concentration and solvent (e.g., [α]D20 2.0±0.4° (c=1%, in methanol)).
  • Solubility: It is generally soluble in organic solvents such as methanol, ethanol, and DMSO, but its solubility in water is limited.

Handling, Storage, and Safety Precautions

Proper handling and storage are critical to maintain the integrity of Boc-L-Aspartic Acid 4-tert-butyl Ester and to ensure laboratory safety. Always consult the Safety Data Sheet (SDS) provided by the manufacturer before use.

  • Storage Conditions: For long-term storage, it is recommended to keep the product at 2-8°C to maintain stability. It should be stored in a tightly sealed container in a dry, well-ventilated area, away from direct sunlight and incompatible materials.
  • Handling: When handling the powder, avoid dust formation. Use appropriate personal protective equipment (PPE), including gloves, eye protection (safety goggles or face shield), and a lab coat. Work in a well-ventilated area or under a fume hood.
  • Incompatibilities: Avoid contact with strong oxidizing agents and strong acids, as these can lead to decomposition or unwanted reactions.
  • Hazard Statements (GHS): As per GHS classification, it may be labeled with signal words like 'Warning' and hazard statements such as H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Precautionary statements P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 should be followed.

By understanding these technical details and adhering to safety guidelines, researchers and procurement specialists can confidently source and utilize Boc-L-Aspartic Acid 4-tert-butyl Ester (CAS 1676-90-0) from reputable manufacturers, ensuring both the quality of their work and their personal safety.