For professionals in chemical synthesis and pharmaceutical development, a thorough understanding of a compound's properties and handling requirements is fundamental to successful laboratory operations. 1-Boc-4-aminoindazole (CAS 801315-74-2) is a vital intermediate with specific characteristics that dictate its optimal use and storage. This technical overview aims to provide researchers and procurement specialists with the essential information needed to effectively work with this compound, including its physical state, stability, and safety protocols.

Physicochemical Profile of 1-Boc-4-aminoindazole

1-Boc-4-aminoindazole, designated by CAS number 801315-74-2 and with the molecular formula C12H15N3O2, presents itself typically as a light yellow to yellow solid. Its molecular weight is approximately 233.27 g/mol. Key predicted physical properties include a density of around 1.24 g/cm3 and a boiling point of approximately 395.3 °C at atmospheric pressure. These properties are consistent with its role as a moderately complex organic molecule. The presence of the Boc protecting group influences its solubility, generally making it soluble in common organic solvents, which is advantageous for reaction processing. While its melting point is not consistently reported, its solid form under standard conditions is well-established.

Optimal Storage and Handling Conditions

To maintain the integrity and purity of 1-Boc-4-aminoindazole, specific storage conditions are recommended. Manufacturers typically advise keeping the compound in a dark place, under an inert atmosphere, and at room temperature. Exposure to light, moisture, and air can lead to degradation over time, compromising its efficacy in synthesis. When handling this chemical, standard laboratory safety practices should be observed. This includes wearing appropriate personal protective equipment (PPE) such as gloves, eye protection (safety goggles or face shield), and a lab coat. It is also important to work in a well-ventilated area or under a fume hood, as indicated by its safety data, which may include hazard statements like H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation).

Importance of Purity for Synthesis

When purchasing 1-Boc-4-aminoindazole, users should prioritize suppliers who guarantee high purity levels, often exceeding 97%. High purity is critical for reproducible results in complex organic synthesis and pharmaceutical development, minimizing the introduction of unwanted side products and ensuring the efficient formation of the target molecule. A clear and accurate Certificate of Analysis (CoA) from the manufacturer detailing purity, assay, and spectral data (like NMR) is indispensable for validating the quality of the material. For those looking to buy this intermediate, especially for large-scale operations, understanding these technical specifications is as important as securing a competitive price.

By adhering to these guidelines for handling and storage, researchers can ensure that 1-Boc-4-aminoindazole remains a reliable and effective component in their synthetic strategies, contributing to advancements in chemical and pharmaceutical research.