For chemists and research scientists engaged in advanced organic synthesis, a thorough understanding of chemical intermediates is crucial. This article provides a technical overview of 2-Bromo-3-fluoropyridin-4-ol, a significant fine chemical characterized by its CAS number 1211525-92-6. We will explore its key chemical properties, typical appearance, and its indispensable role as a building block in modern chemical research.

Chemical Profile of 2-Bromo-3-fluoropyridin-4-ol

Chemical Name: 2-Bromo-3-fluoropyridin-4-ol
CAS Number: 1211525-92-6
Molecular Formula: C₅H₃BrFNO
Molecular Weight: Approximately 191.99 g/mol

Physical and Chemical Properties:

  • Appearance: Typically supplied as a white to off-white solid. This physical state is common for many organic compounds of similar molecular weight and structure.
  • Purity: High-purity grades, often exceeding 95% and sometimes reaching up to 99% by HPLC, are generally available from reputable suppliers to meet the stringent demands of pharmaceutical synthesis.
  • Solubility: While specific solubility data may vary, compounds with hydroxyl groups and pyridine rings often exhibit moderate solubility in polar organic solvents like DMSO, DMF, and alcohols, and limited solubility in non-polar solvents.
  • Reactivity: The molecule contains several functional groups that contribute to its synthetic utility:
    • The bromine atom at the 2-position is amenable to various cross-coupling reactions (e.g., Suzuki, Stille, Buchwald-Hartwig), enabling the introduction of carbon-carbon and carbon-heteroatom bonds.
    • The fluorine atom at the 3-position can influence electron distribution and metabolic stability, common considerations in drug design.
    • The hydroxyl group at the 4-position can undergo derivatization, such as etherification, esterification, or can participate in tautomerization.

Synthetic Utility and Applications

2-Bromo-3-fluoropyridin-4-ol serves as a versatile scaffold for chemists aiming to synthesize complex molecules. Its applications predominantly lie in:

  • Pharmaceutical Intermediate: It is widely used in the synthesis of various Active Pharmaceutical Ingredients (APIs) and drug candidates. Researchers often buy this compound to build novel heterocyclic drug structures.
  • Agrochemical Synthesis: Similar to pharmaceuticals, its unique structure can be beneficial in developing new pesticides, herbicides, or fungicides.
  • Materials Science: Fluorinated pyridine derivatives can be explored for their electronic or optical properties in advanced materials.

Sourcing Considerations for Chemists

When sourcing 2-Bromo-3-fluoropyridin-4-ol, chemists should consult detailed product specifications from suppliers. Understanding the storage conditions (often recommended at 2-8°C under inert gas for stability) and handling precautions is essential. Obtaining a quote from a trusted fine chemical supplier that guarantees purity and provides comprehensive technical support is key to successful project execution.

The strategic combination of functional groups makes 2-Bromo-3-fluoropyridin-4-ol a cornerstone intermediate for many synthetic chemists. Its availability from reliable manufacturers ensures that innovation in chemistry and pharmaceuticals can continue to advance.