For chemists and formulators, a deep understanding of the technical specifications of chemical intermediates is vital for successful project execution. This article provides a detailed look at 2-Bromo-4'-methoxyacetophenone (CAS 2632-13-5), covering its key properties, synthesis pathways, and practical applications.

Chemical Identity and Physicochemical Properties

2-Bromo-4'-methoxyacetophenone, with the CAS number 2632-13-5, is an organic compound represented by the molecular formula C9H9BrO2. It typically presents as a white to light brown crystalline powder or solid, with a melting point range of 69-71 °C. Its chemical structure features an acetophenone backbone substituted with a bromine atom at the alpha position and a methoxy group at the para position of the phenyl ring. This structure confers specific reactivity, making it a useful reagent in various organic transformations. Its solubility profile indicates it is soluble in DMSO, water (partly miscible), most organic solvents, and methanol, facilitating its use in diverse reaction media.

Synthesis and Preparation Methods

The preparation of 2-Bromo-4'-methoxyacetophenone commonly involves the alpha-bromination of 4-methoxyacetophenone. A typical synthesis route includes reacting 4-methoxyacetophenone with a brominating agent, such as N-bromosuccinimide (NBS), often in the presence of a catalyst like trimethylsilyl trifluoromethanesulfonate (TMS-OTf) in a suitable solvent like acetonitrile. The reaction conditions are optimized to yield the desired product with high purity, often around 98% or more. For buyers seeking this compound, understanding these synthesis routes can help in evaluating the quality and consistency offered by different manufacturers.

Applications in Organic Synthesis and Beyond

The primary application of 2-Bromo-4'-methoxyacetophenone lies in its role as a versatile intermediate in organic synthesis. It is frequently used in the preparation of pharmaceuticals and agrochemicals, where its reactive functional groups allow for further molecular elaboration. Moreover, its property as a potent inhibitor of protein tyrosine phosphatases (PTPs) makes it a valuable compound for biochemical research. Scientists exploring PTP-related diseases, such as diabetes and neurological disorders, often look to buy this chemical to study enzyme kinetics and structure-activity relationships. The availability from reliable suppliers ensures that researchers can easily obtain this specialized reagent for their laboratory work.

Procurement and Handling Considerations

When purchasing 2-Bromo-4'-methoxyacetophenone, technical specifications like purity, CAS number, and physical form are crucial. Buyers should consult Material Safety Data Sheets (MSDS) for comprehensive safety information, as this compound can be corrosive and may cause skin and eye irritation. Working with experienced manufacturers and suppliers, particularly those offering global shipping, ensures that these specialized chemicals can be obtained efficiently and handled safely throughout the supply chain.