For professionals in the chemical and pharmaceutical industries, a thorough understanding of key intermediates is vital for innovation and efficient production. 5-Bromothiophene-3-carboxylic Acid (CAS 100523-84-0) is a compound that warrants close examination due to its significant utility as a versatile building block. This article delves into its chemical characteristics, typical synthesis pathways, and its impactful applications, particularly for those looking to buy and utilize this compound in their research and manufacturing processes.

Chemical Profile and Reactivity

5-Bromothiophene-3-carboxylic Acid is characterized by its thiophene ring, substituted with a bromine atom at the 5-position and a carboxylic acid group at the 3-position. This arrangement confers distinct reactivity. The bromine atom is an excellent leaving group, making the molecule highly amenable to various palladium-catalyzed cross-coupling reactions. These include Suzuki-Miyaura coupling for C-C bond formation with boronic acids, Stille coupling with organostannanes, and Heck reactions with alkenes, all of which are cornerstones of modern organic synthesis. The carboxylic acid moiety can undergo standard derivatization reactions, such as esterification, amidation, or conversion to acid chlorides, allowing for further functionalization and the introduction of diverse substituents. Its typical appearance as a white crystal powder, with a purity often exceeding 99.0%, underscores its suitability for sensitive synthetic procedures.

Synthesis Pathways and Manufacturing Considerations

While specific industrial synthesis routes are proprietary, the preparation of 5-Bromothiophene-3-carboxylic Acid generally involves electrophilic bromination of thiophene-3-carboxylic acid or related precursors. The regioselectivity of bromination is a key challenge in its synthesis, often requiring careful control of reaction conditions, catalysts, and protecting groups to achieve the desired 5-bromo isomer. Manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. have optimized these processes to ensure high yield and purity, delivering the product in secure packaging like 25kg fiber drums. For those looking to purchase this intermediate, inquiring about the supplier's manufacturing expertise and quality control measures is crucial.

Critical Applications in Research and Development

The primary application of 5-Bromothiophene-3-carboxylic Acid lies in its role as a pharmaceutical intermediate. It serves as a foundational component in the synthesis of numerous APIs and drug candidates, contributing to the development of treatments across various therapeutic areas. Beyond pharmaceuticals, this compound finds utility in materials science, particularly in the synthesis of conductive polymers and organic electronic components where thiophene derivatives are often employed for their electronic and optical properties. Researchers and industrial chemists seeking to buy this compound for their projects will find NINGBO INNO PHARMCHEM CO.,LTD. to be a reliable source, offering consistent quality and a stable supply chain.

Understanding the technical aspects of 5-Bromothiophene-3-carboxylic Acid allows for its effective utilization. When you need to buy this critical intermediate, remember that partnering with an experienced manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures you receive a high-quality product that meets stringent industry standards, facilitating your R&D and manufacturing endeavors.