For chemists and materials scientists, a thorough understanding of a chemical's properties is fundamental to its effective use. 4-Amino-2,6-dichloropyrimidine, identified by its CAS number 10132-07-7, is a compound that warrants detailed examination of its physicochemical attributes. This article delves into the technical specifications that define this important heterocyclic intermediate.

Chemical Identity and Structure

The chemical name 4-Amino-2,6-dichloropyrimidine clearly describes its structure: a pyrimidine ring substituted with an amino group at the 4-position and chlorine atoms at the 2 and 6 positions. Its molecular formula is C₄H₃Cl₂N₃, and its molecular weight is approximately 163.99 g/mol. The EINECS number, 233-369-3, is a unique identifier in the European chemical registry.

Physical Appearance and Form

In its pure form, 4-Amino-2,6-dichloropyrimidine typically presents as a white to pale brown powder or crystalline powder. This consistent physical appearance is an important quality indicator for manufacturers and buyers. The crystalline nature suggests a well-defined molecular structure and often correlates with higher purity.

Key Physicochemical Properties

Understanding the following properties is crucial for handling and application:

  • Melting Point: The melting point for 4-Amino-2,6-dichloropyrimidine is generally reported in the range of 258-267°C. This relatively high melting point indicates a stable solid form under standard conditions and is a key parameter for quality control and identification.
  • Water Solubility: Its solubility in water is described as slightly soluble. This suggests that while it can be dissolved in aqueous solutions to some extent, it may require co-solvents or specific conditions for complete dissolution, which is important for reaction design and formulation.
  • Storage Temperature: Recommended storage conditions are typically between 2-8°C. This temperature range is crucial for maintaining the compound's stability and preventing degradation over time. Proper storage is essential for suppliers to ensure product integrity upon delivery.

Safety and Handling Information

As indicated by hazard codes such as Xn (Harmful) and Xi (Irritant), 4-Amino-2,6-dichloropyrimidine requires careful handling. Safety statements often include precautions related to avoiding contact with skin, eyes, and clothing, and ensuring adequate ventilation. For anyone looking to buy or use this chemical, consulting the comprehensive Safety Data Sheet (SDS) provided by the manufacturer or supplier is paramount. This document details hazard identification, first-aid measures, fire-fighting measures, accidental release measures, and more.

Reactivity and Use in Synthesis

The two reactive chlorine atoms on the pyrimidine ring are particularly important for its application as a chemical intermediate. They are susceptible to nucleophilic substitution reactions, allowing for the introduction of various functional groups. This reactivity is what makes 4-Amino-2,6-dichloropyrimidine a valuable building block in organic synthesis, particularly for pharmaceutical intermediates, as it enables the construction of more complex molecular architectures required for drug discovery and development. Manufacturers and suppliers play a vital role in providing this compound with the necessary purity and stability for these intricate synthetic processes.

By understanding these detailed chemical properties, R&D scientists and procurement specialists can make informed decisions when sourcing and utilizing 4-Amino-2,6-dichloropyrimidine for their specific chemical needs.