For organic chemists and research scientists, understanding the synthesis and chemical behavior of key intermediates is crucial for innovation. This article delves into the technical profile of 4-[(5-bromo-4,6-dichloro-2-pyrimidinyl)amino]benzonitrile (CAS 269055-75-6), a compound widely used in the synthesis of pharmaceuticals and potentially in advanced cosmetic applications. We explore its molecular structure, reactivity, and the importance of sourcing high-purity material from reliable manufacturers.

Molecular Structure and Reactivity Insights

The compound, with the chemical formula C11H5BrCl2N4 and a molecular weight of 343.99 g/mol, features a benzonitrile moiety linked to a halogenated pyrimidine ring. The presence of bromine and chlorine atoms on the pyrimidine ring, coupled with the nitrile group on the phenyl ring, offers multiple sites for diverse chemical transformations. This structural complexity makes it a valuable building block in multi-step organic synthesis. Chemists can exploit the reactivity of the halogen atoms for nucleophilic substitution reactions or cross-coupling processes, while the nitrile group can be further functionalized.

Significance in Pharmaceutical Synthesis

As a pharmaceutical intermediate, 4-[(5-bromo-4,6-dichloro-2-pyrimidinyl)amino]benzonitrile plays a vital role in constructing complex drug molecules. Its specific arrangement of functional groups allows for targeted synthesis of compounds with desired pharmacological activities. The reliability of its supply, with a standard purity of 98%, ensures that research and development projects can proceed without interruption due to material quality issues. Purchasing from established chemical manufacturers ensures a consistent and high-quality source for these critical projects.

Analytical Characterization and Quality Control

For scientists and researchers, a detailed understanding of the compound's analytical data is essential. Key characterization parameters include purity, typically verified by techniques like HPLC or GC. The melting point and boiling point (524.308 °C) are indicative of its physical properties. Manufacturers who provide comprehensive documentation, including Safety Data Sheets (SDS) and Certificates of Analysis (CoA), are invaluable partners for any chemical synthesis endeavor.

Sourcing Strategies for R&D and Bulk Needs

Researchers and procurement specialists looking to buy 4-[(5-bromo-4,6-dichloro-2-pyrimidinyl)amino]benzonitrile need to consider both R&D-scale quantities and potential bulk manufacturing needs. Reputable suppliers, especially those based in China, offer flexible MOQs and competitive pricing structures. Understanding payment terms (T/T, L/C) and shipping Incoterms (FOB, CIF) is crucial for efficient procurement. The ability to source from reliable manufacturers ensures access to this important chemical building block for both discovery and scaled production.

Conclusion

4-[(5-bromo-4,6-dichloro-2-pyrimidinyl)amino]benzonitrile (CAS 269055-75-6) is a testament to the power of specialized chemical intermediates in driving scientific advancement. Its unique structure and reactivity make it a cornerstone in many synthetic pathways. By partnering with knowledgeable manufacturers and suppliers who prioritize quality and technical support, researchers and chemists can confidently integrate this compound into their innovative projects.