For chemists and chemical engineers working with specialized intermediates, a thorough understanding of product properties and safe handling is paramount. 3-(Trifluoromethyl)benzyl Bromide (CAS: 402-23-3) is a reactive organic compound that plays a crucial role in various synthetic applications. This article provides technical insights into its characteristics, common uses, and essential handling recommendations, emphasizing the importance of sourcing from reliable manufacturers.

Key Technical Specifications and Properties

3-(Trifluoromethyl)benzyl Bromide is a compound that chemists rely on for introducing specific structural motifs into target molecules. Its defining technical features include:

  • Chemical Formula: C8H6BrF3
  • Molecular Weight: 239.04 g/mol
  • CAS Number: 402-23-3
  • Appearance: Typically described as a colorless to light yellow liquid.
  • Purity: Manufacturers commonly offer this compound with a purity of >98.0% (GC), crucial for predictable reaction outcomes.
  • Boiling Point: Approximately 69 °C at 4 mmHg, indicating its volatility under reduced pressure.
  • Density: Around 1.565 g/mL at 25 °C.
  • Refractive Index: n20/D around 1.492.
  • Flash Point: Typically around 87°C (188°F), classifying it as a combustible liquid.
  • Storage: It is often recommended to store in a dark place, under an inert atmosphere, and at room temperature to maintain its stability. It can be sensitive to light and moisture.

Applications Driven by Its Reactivity

The reactive benzyl bromide moiety, coupled with the electron-withdrawing trifluoromethyl group, makes this compound highly useful:

  • Pharmaceutical Synthesis: It is a precursor for many APIs and drug candidates, contributing to enhanced efficacy and pharmacokinetic properties due to the trifluoromethyl group.
  • Agrochemicals: Used in the synthesis of pest control agents, such as flocoumafen, where the -CF3 group aids in potency and stability.
  • General Organic Synthesis: Serves as a valuable building block for creating complex organic molecules in research and industrial settings.

Safe Handling and Storage Practices

As a reactive chemical, 3-(Trifluoromethyl)benzyl Bromide requires careful handling:

  • Personal Protective Equipment (PPE): Always wear appropriate PPE, including chemical-resistant gloves, safety goggles, and lab coats. Work in a well-ventilated area or fume hood.
  • Lachrymatory Properties: Be aware that benzyl bromides can be lachrymatory (cause tears). Avoid inhalation of vapors.
  • Compatibility: Keep away from strong oxidizing agents, strong bases, and moisture.
  • Spill Management: Have appropriate spill containment and cleanup materials readily available.

For any chemical sourcing, especially for reactive intermediates, partnering with a reputable manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures you receive accurate technical data, high-quality products, and guidance on safe handling practices. Accessing reliable technical information and quality-assured materials is key to successful and safe chemical operations.