For professionals engaged in chemical synthesis, particularly in the pharmaceutical sector, precise technical specifications for intermediates are non-negotiable. 1H-Imidazol-1-ylacetonitrile (CAS 98873-55-3), a vital precursor for antifungal APIs like Luliconazole, requires a thorough understanding of its critical technical parameters.

The most fundamental specification is its appearance: typically a white to off-white powder. This physical characteristic provides a first visual indicator of product quality. However, the true measure of its suitability lies in its chemical purity. The industry standard for 1H-Imidazol-1-ylacetonitrile is an assay of ≥98.0% as determined by High-Performance Liquid Chromatography (HPLC). This ensures that the compound is sufficiently pure for sensitive synthetic reactions.

Beyond the primary assay, attention must be paid to impurity profiles. Specifications for 'single impurity' and 'total impurities' are crucial. Generally, a single impurity should not exceed 0.5%, and the sum of all impurities should be kept below 1.0%. These limits are critical because impurities can interfere with reaction pathways, reduce yield, and potentially contaminate the final pharmaceutical product, leading to regulatory issues.

Another important specification is the 'loss on drying' (LOD), which indicates the residual moisture or volatile content. For 1H-Imidazol-1-ylacetonitrile, a low LOD of ≤0.5% is typically required. This is important for accurate weighing and to prevent unwanted side reactions in moisture-sensitive chemical processes.

When you purchase CAS 98873-55-3, always request a detailed Certificate of Analysis (CoA) from your supplier. This document will confirm that the material meets all specified technical parameters. Understanding these specifications empowers you to make informed decisions about suppliers and ensures the successful execution of your chemical synthesis projects. As a reliable manufacturer, we provide comprehensive technical data to support your needs.