For professionals in the pharmaceutical and chemical industries, a deep understanding of technical specifications is crucial when selecting raw materials. 2-(2-Aminothiazol-4-yl)acetic Acid Hydrochloride (CAS: 66659-20-9) is a vital intermediate, and knowing its properties ensures optimal use in synthesis, particularly for cephalosporin antibiotics like Cefotiam.

Chemical Identity and Properties

This compound is characterized by its molecular formula C5H7ClN2O2S and a molecular weight of approximately 194.64 g/mol. As supplied by reputable manufacturers, it typically presents as a White to Off-White crystalline powder. Its physical properties, such as melting point (around 152°C) and solubility in certain solvents, are important considerations for process development.

Synthesis and Purity Standards

The synthesis of 2-(2-Aminothiazol-4-yl)acetic Acid Hydrochloride often involves multi-step chemical reactions, with patented methods focusing on efficiency and minimizing environmental impact. For pharmaceutical applications, a high degree of purity is paramount. Manufacturers aim for a purity of ≥98.0%, often verified through advanced analytical techniques like HPLC. This commitment to purity ensures that the intermediate will perform reliably in subsequent synthesis steps.

Applications in Pharmaceutical Manufacturing

The primary application of this chemical is as a key intermediate in the synthesis of Cefotiam, a broad-spectrum antibiotic. Its specific chemical structure makes it an ideal precursor, enabling the efficient construction of the complex cephalosporin molecule. Pharmaceutical companies looking to buy this intermediate should always confirm the supplier's expertise in pharmaceutical chemical manufacturing and their adherence to quality control protocols.

Procurement and Technical Support

When sourcing 2-(2-Aminothiazol-4-yl)acetic Acid Hydrochloride, engaging with manufacturers directly is advisable. Companies like NINGBO INNO PHARMCHEM CO.,LTD. can provide detailed technical data sheets, safety information (MSDS), and pricing based on your required quantities. Understanding these technical specifications empowers R&D scientists and procurement managers to make informed decisions and ensure the successful integration of this crucial intermediate into their production processes.