For chemists and researchers engaged in advanced organic synthesis, a thorough understanding of intermediate compounds is essential for successful project outcomes. 4-Fluoro-2-(trifluoromethyl)benzoic Acid (CAS: 141179-72-8) is a prime example of such a valuable building block, offering a unique combination of chemical functionalities that drive innovation in various fields, from pharmaceuticals to materials science. This technical spotlight aims to provide detailed insights into its properties and applications.

Chemical Identity and Physical Properties

Chemical Name: 4-Fluoro-2-(trifluoromethyl)benzoic Acid
CAS Number: 141179-72-8
Molecular Formula: C8H4F4O2
Molecular Weight: 208.11
Appearance: White crystalline powder
Purity (Assay): ≥99.0%
Melting Point: 121-124 °C
Boiling Point: Approximately 239 °C (though decomposition may occur at high temperatures)
Flash Point: 98.3 °C
Moisture Content: ≤0.5%
Solubility: Generally insoluble in water but soluble in many common organic solvents such as ethers, alcohols, and chlorinated hydrocarbons.

These properties define its handling, storage, and reactivity in synthetic processes. The high melting point indicates a stable solid form, while its solubility profile is critical for choosing appropriate reaction media.

Key Applications in Organic Synthesis

The structural features of 4-Fluoro-2-(trifluoromethyl)benzoic Acid make it a versatile intermediate for synthesizing complex organic molecules:

  • Pharmaceutical Industry: It serves as a key building block for a range of APIs, contributing fluorinated motifs that can enhance metabolic stability, improve lipophilicity, and modulate receptor binding. It is utilized in the synthesis of drugs targeting various therapeutic areas.
  • Agrochemical Sector: Used in the development of advanced pesticides, herbicides, and fungicides. The fluorine and trifluoromethyl groups can increase the bioactivity and environmental persistence of the active ingredients.
  • Materials Science: Potentially used in the synthesis of specialty polymers, liquid crystals, or electronic materials where specific thermal, optical, or electronic properties are required due to the fluorine substitution.
  • General Organic Synthesis: As a versatile carboxylic acid derivative, it can undergo various transformations such as esterification, amidation, reduction, and coupling reactions to create a broad spectrum of fine chemicals.

Procurement Considerations for Researchers

Researchers and procurement specialists looking to buy 4-Fluoro-2-(trifluoromethyl)benzoic Acid should prioritize sourcing from reputable manufacturers and suppliers. Ensuring a purity level of ≥99.0% is critical for reliable experimental results and efficient scale-up. When sourcing from China, it is advisable to request comprehensive technical data, including a CoA, and to compare offerings from multiple suppliers to secure the best combination of quality and price.

In conclusion, 4-Fluoro-2-(trifluoromethyl)benzoic Acid is an indispensable intermediate for professionals in chemical research and development. Its well-defined properties and broad applicability underscore its importance in creating innovative products across multiple industries.