For chemists, engineers, and safety officers, a thorough understanding of chemical properties and handling protocols is fundamental. 2-Chloro-4-fluorobenzenesulfonyl Chloride (CAS: 85958-57-2) is a reactive intermediate that requires specific attention to detail regarding its characteristics and safe usage. This technical spotlight aims to provide key information for those working with this compound.

Physically, 2-Chloro-4-fluorobenzenesulfonyl Chloride is typically observed as a yellow liquid. Its melting point is in the range of 27-31 °C, meaning it can solidify at cooler ambient temperatures. The boiling point is recorded at approximately 243-244 °C. Its density is around 1.569 g/mL at 25 °C. A critical characteristic is its moisture sensitivity. This means it reacts with water, potentially hydrolyzing into corresponding sulfonic acid and hydrochloric acid, which can affect its purity and usability for synthesis. Therefore, it must be stored under dry conditions, preferably in sealed containers under an inert atmosphere, such as nitrogen or argon, to prevent degradation.

Chemically, the compound's reactivity is dominated by the sulfonyl chloride functional group. This group is an excellent leaving group, readily participating in nucleophilic substitution reactions. Common reactions include its treatment with amines to form sulfonamides, with alcohols to form sulfonic esters, and with phenols. These reactions are foundational in constructing molecules with diverse functionalities. The presence of chlorine and fluorine on the aromatic ring influences its electronic nature and can direct further substitution reactions or be involved in cross-coupling chemistry.

Handling 2-Chloro-4-fluorobenzenesulfonyl Chloride requires strict adherence to safety protocols. As a sulfonyl chloride, it is corrosive and can cause severe skin burns and eye damage. Inhalation of vapors may cause respiratory irritation. Personal protective equipment (PPE) is mandatory, including chemical-resistant gloves (such as nitrile or neoprene), safety goggles with side shields, and a lab coat. Work should ideally be conducted in a well-ventilated area or a fume hood. In case of contact, immediate flushing with plenty of water is advised, followed by medical attention if necessary. Safety Data Sheets (SDS) from the manufacturer should always be consulted for comprehensive safety information.

For professionals looking to buy 2-Chloro-4-fluorobenzenesulfonyl Chloride, ensuring that your supplier provides accurate technical documentation and prioritizes product integrity is vital. Reputable manufacturers, like NINGBO INNO PHARMCHEM CO.,LTD., are committed to delivering high-quality products with detailed specifications and safety guidance. Understanding these technical aspects ensures efficient and safe utilization of this important chemical intermediate in your laboratory or manufacturing processes.