For researchers and chemists engaged in drug discovery and development, understanding the synthesis and application of key chemical intermediates is fundamental. Tert-Butyl 4-aminobenzoate, identified by CAS number 18144-47-3, is one such compound that plays a crucial role in creating novel therapeutic agents. Its specific chemical structure makes it an invaluable building block, and securing a reliable source for this intermediate is often a priority for R&D teams.

Synthesis of Tert-Butyl 4-Aminobenzoate

The synthesis of Tert-Butyl 4-aminobenzoate typically involves the reduction of its nitro precursor, Tert-butyl 4-nitrobenzoate. This common synthetic route, often carried out using hydrogenation catalyzed by palladium on carbon (Pd/C) in a solvent like methanol, efficiently converts the nitro group to an amine. The process yields the desired product with high purity, often appearing as a white to light yellow crystalline powder. Precise control over reaction conditions ensures minimal byproducts, a critical factor for pharmaceutical applications. If you are looking to buy this compound, understanding its synthesis can help you assess the quality offered by different suppliers.

Diverse Applications in Pharmaceutical Research

The primary allure of Tert-Butyl 4-aminobenzoate lies in its broad utility within medicinal chemistry. It is extensively used as a structural unit in the synthesis of antifolate drugs. Antifolates are a class of compounds that inhibit folate metabolism, making them effective in treating various cancers and parasitic infections. For example, it can be used in the synthesis of novel liver-targeted couplings of glycogen phosphorylase inhibitors for diabetes treatment, showcasing its versatility beyond traditional antifolate applications.

Furthermore, Tert-Butyl 4-aminobenzoate serves as a precursor for N-substituted derivatives, expanding its scope in creating a wide array of complex molecules. Drug developers utilize it to build intricate scaffolds for potential new treatments, exploring diverse pharmacological targets. Its incorporation into various drug candidates underscores its significance as an advanced API intermediate.

Securing Your Supply Chain

For drug development projects, a consistent and high-quality supply of Tert-Butyl 4-aminobenzoate is essential. When searching for 'tert-butyl 4-aminobenzoate price' or 'where to purchase tert-butyl 4-aminobenzoate', it is crucial to partner with reputable manufacturers and suppliers. Companies offering this compound often provide detailed specifications, including melting points (around 108-110 °C) and assays (≥99.0%). Engaging with a knowledgeable supplier can provide not only the material but also technical support and customized packaging solutions to meet specific project needs. Consider exploring options from established chemical hubs, such as China, for competitive pricing and robust supply capabilities.

In conclusion, Tert-Butyl 4-aminobenzoate (CAS 18144-47-3) is a cornerstone intermediate for drug developers. Its straightforward synthesis and wide-ranging applications in creating potent therapeutic agents make it a highly sought-after compound. By understanding its chemical properties and securing a reliable supply, research teams can accelerate their progress in bringing new medicines to market.