Tert-Butyl bromoacetate, identified by its CAS number 5292-43-3, is a chemical compound of considerable importance in the fields of organic chemistry and pharmaceuticals. Characterized as a clear, colorless to slight yellow liquid, this substance, also known by synonyms like tert-butyl 2-bromoacetate, is defined by its molecular formula C6H11BrO2 and a molecular weight of approximately 195.06 g/mol.

The compound's primary role in the chemical industry is as a pharmaceutical intermediate. It is a crucial component in the synthesis of amino acids and peptide compounds, which are foundational elements in the development of many therapeutic drugs. Its application extends to the creation of specialized pharmaceuticals such as collagenase inhibitors and cephalosporins. This makes Tert-Butyl bromoacetate a vital ingredient for companies engaged in drug discovery and development.

Beyond its pharmaceutical applications, Tert-Butyl bromoacetate is also recognized as a common alkylating agent. In organic synthesis, this property allows it to efficiently introduce alkyl groups into various molecules. This is essential for modifying molecular structures to achieve specific chemical or biological functions. Its use in synthesizing isoquinoline derivatives and as an alkylating agent in various research settings highlights its versatility.

The synthesis of Tert-Butyl bromoacetate typically involves reactions like the esterification of bromoacetic acid with tert-butanol, or reacting tert-butanol with bromoacetyl bromide. Manufacturers, particularly those in China, focus on optimizing these processes to ensure high purity, often above 98%, and reliable production volumes. Companies like NINGBO INNO PHARMCHEM CO.,LTD. provide this chemical with strict quality control, ensuring it meets the demanding specifications required by the pharmaceutical and fine chemical sectors.

Understanding the physical and chemical properties is key for safe and effective use. While its exact boiling point can vary slightly with pressure, it's generally around 164°C at atmospheric pressure, with a flash point of approximately 59.1°C. Its solubility in organic solvents like ethanol and chloroform, while being immiscible with water, guides its application in various reaction media. Proper handling and storage, as recommended by suppliers, are essential due to its flammability and potential irritant properties.

In essence, Tert-Butyl bromoacetate (CAS 5292-43-3) stands out as a valuable and versatile chemical intermediate. Its critical role in pharmaceutical synthesis and its utility as an alkylating agent make it indispensable for advancements in chemistry and medicine. Sourcing from reputable manufacturers ensures the quality and reliability needed for critical applications.