In the realm of pharmaceutical manufacturing, the availability of high-quality intermediates is the bedrock of innovation and production. Tetraacetylribofuranose (CAS 13035-61-5) stands out as a critically important compound, serving as a versatile building block for a wide range of pharmaceutical applications. This article provides an overview for professionals looking to understand and buy this essential intermediate, focusing on its applications and sourcing strategies.

What is Tetraacetylribofuranose?

Tetraacetylribofuranose is a protected derivative of D-ribose, a five-carbon sugar that is a fundamental component of RNA. The acetylation process protects the reactive hydroxyl groups, enhancing the compound's stability and solubility in organic solvents, which is crucial for synthetic chemistry. Its chemical structure, C13H18O9, and its typical presentation as a white crystalline powder with high purity (≥98%) make it a reliable reagent for complex organic synthesis.

Key Applications in the Pharmaceutical Industry

The utility of Tetraacetylribofuranose spans several key areas:

  • Nucleoside Synthesis: It is a vital starting material for creating nucleosides and nucleotides, the building blocks of DNA and RNA. This capability is essential for research into genetic disorders, cancer therapies, and antiviral drug development.
  • Antiviral Drug Manufacturing: This intermediate is indispensable for synthesizing antiviral agents, most notably Ribavirin, which is used to treat conditions like hepatitis C and respiratory syncytial virus (RSV) infections. Consistent sourcing from a trusted manufacturer ensures production continuity.
  • Drug Discovery and Development: Medicinal chemists utilize Tetraacetylribofuranose to synthesize novel compounds with potential therapeutic activities, including anticancer agents and other modified nucleoside analogs. Researchers often seek to obtain a quote for R&D quantities.
  • Biochemical Research: Beyond drug synthesis, it serves as a tool in glycobiology and carbohydrate chemistry for studying cellular processes and molecular interactions.

How to Buy Tetraacetylribofuranose

For pharmaceutical companies and research institutions, securing a reliable supply of Tetraacetylribofuranose is paramount. When looking to purchase this compound, consider the following:

  • Supplier Selection: Identify reputable manufacturers and suppliers, particularly those with a strong track record in producing high-purity pharmaceutical intermediates. Many leading chemical companies based in China offer competitive pricing and quality products.
  • Quality Verification: Always request Certificates of Analysis (CoA) to confirm purity and specifications.
  • Pricing and Bulk Orders: Obtaining multiple quotes for bulk quantities can help secure better pricing and ensure long-term supply stability.
  • Technical Support: Partner with suppliers who provide comprehensive technical data and support, aiding in your research and manufacturing processes.

By focusing on these aspects, professionals can ensure they are sourcing high-quality Tetraacetylribofuranose, a compound critical for advancing pharmaceutical research and production.