Tetrazole: A Key Intermediate for DNA Synthesis & Beyond
Tetrazole, a nitrogen-rich heterocyclic compound with the CAS number 288-94-8, is recognized for its multifaceted applications extending beyond its well-established role in pharmaceuticals. While its significance as a pharmaceutical intermediate, particularly for drugs like Cilostazol and as a bioisostere for carboxylate groups, is widely acknowledged, its utility in other cutting-edge fields is also gaining prominence.
One such area is DNA synthesis. Tetrazole and its derivatives are employed as coupling reagents or activators in the phosphoramidite method of oligonucleotide synthesis. This process is fundamental to genetic research, diagnostics, and the burgeoning field of DNA-based therapeutics. The ability of Tetrazole to facilitate efficient phosphite triester formation is crucial for building complex DNA strands with high fidelity. For researchers and chemical synthesis companies, securing a reliable supply of high-purity Tetrazole is essential for advancing genomic technologies. When looking to buy Tetrazole for these applications, prioritizing purity and consistent reactivity is key.
Furthermore, the high nitrogen content of Tetrazole makes it an attractive candidate for the development of energetic materials. Tetrazole derivatives have been investigated for their potential use in high-performance explosives and solid rocket propellant formulations. These materials offer advantages such as producing non-toxic combustion products like nitrogen gas and water, alongside high burn rates and relative stability. While this application is specialized, it highlights the extreme versatility of the Tetrazole scaffold. Manufacturers in China are increasingly capable of producing Tetrazole to meet the demanding specifications required for such advanced material science research.
The chemical industry's demand for Tetrazole stems from its unique structural features and reactivity. As a supplier, offering Tetrazole with a purity of ≥99% ensures its suitability for these diverse, high-stakes applications. Procurement managers seeking to purchase Tetrazole for DNA synthesis or materials research will find that domestic Chinese manufacturers provide competitive pricing and substantial production capacities. This makes China a strategic sourcing hub for global clients.
In essence, Tetrazole (CAS 288-94-8) is a chemical workhorse with applications that span from intricate biochemical processes to powerful material science innovations. Whether you are developing new pharmaceuticals, synthesizing custom DNA sequences, or exploring novel energetic compounds, high-quality Tetrazole from a trusted supplier is a critical component. Engaging with leading Tetrazole manufacturers in China can provide the necessary quality, quantity, and cost-effectiveness for your projects.
Perspectives & Insights
Data Seeker X
“This process is fundamental to genetic research, diagnostics, and the burgeoning field of DNA-based therapeutics.”
Chem Reader AI
“The ability of Tetrazole to facilitate efficient phosphite triester formation is crucial for building complex DNA strands with high fidelity.”
Agile Vision 2025
“For researchers and chemical synthesis companies, securing a reliable supply of high-purity Tetrazole is essential for advancing genomic technologies.”