For chemists engaged in advanced organic synthesis, a thorough understanding of the chemical profile and synthesis pathways of key intermediates is indispensable. 2,6-Dichloro-4-(trifluoromethoxy)aniline, identified by CAS number 99479-66-0, is a compound of considerable interest due to its structural features and reactivity. This article aims to provide R&D chemists with a concise overview of its properties, melting point, and common synthesis routes, thereby facilitating its effective use in various chemical transformations. It also touches upon sourcing considerations for this important intermediate.

Chemically, 2,6-Dichloro-4-(trifluoromethoxy)aniline is an aniline derivative characterized by a benzene ring substituted with two chlorine atoms at the ortho positions (2 and 6), an amino group (-NH2) at the para position (1), and a trifluoromethoxy group (-OCF3) at the meta position (4). Its molecular formula is C7H4Cl2F3NO, and its molecular weight is approximately 246.01 g/mol. The compound typically appears as a white powder and exhibits a melting point in the range of 30-32°C. This relatively low melting point suggests it can be handled easily in laboratory settings. Its boiling point is reported around 60-62°C at a reduced pressure (1 mmHg), indicating reasonable volatility under vacuum.

The synthesis of 2,6-Dichloro-4-(trifluoromethoxy)aniline often involves multi-step processes starting from readily available precursors. One established route, as described in patent literature, begins with p-Chlorobenzotrifluoride. This starting material undergoes halogenation reactions, followed by ammoniation. For instance, p-Chlorobenzotrifluoride can be reacted with chlorine in the presence of a catalyst to form intermediate chlorinated products, which are then subjected to ammoniation under specific temperature and pressure conditions to yield the desired aniline derivative. Optimization of reaction conditions, catalysts, and reactant ratios is crucial for maximizing yield and purity.

For R&D chemists, procuring 2,6-Dichloro-4-(trifluoromethoxy)aniline from reliable chemical suppliers is essential for successful project outcomes. When choosing to buy this compound, it is advisable to work with manufacturers who can provide detailed specifications, including purity analysis (e.g., GC analysis results) and safety information (SDS). Understanding these aspects ensures that the purchased material is suitable for intended research applications. Whether you are synthesizing agrochemicals, pharmaceuticals, or novel organic materials, having access to well-characterized intermediates like 2,6-dichloro-4-(trifluoromethoxy)aniline is fundamental to driving scientific progress. Consider consulting with chemical manufacturers in China for high-quality, cost-effective sourcing options.