Ningbo Inno Pharmchem Co., Ltd. is pleased to present a detailed overview of 4-Amino-3,5-dichloroacetophenone (CAS: 37148-48-4), a compound of significant interest in the realm of fine chemicals and pharmaceutical intermediates. This article will explore its core chemical characteristics and the established synthesis pathways that make it a valuable commodity in the chemical industry.

The chemical profile of 4-Amino-3,5-dichloroacetophenone is defined by its molecular formula C8H7Cl2NO and a molecular weight of 204.05. Key physical properties include a melting point typically ranging from 162-166 °C, indicating it is a solid at room temperature, appearing as a white to light yellow crystal powder. Its solubility characteristics are also noteworthy; it is largely insoluble in cold water but shows slight solubility in hot water and is more soluble in organic solvents like ethanol and ether. These properties are vital for its handling, storage, and application in various chemical processes.

The synthesis of 4-amino-3,5-dichloroacetophenone is a critical aspect of its industrial production. One prominent method involves the chlorination of 4-aminoacetophenone. This reaction can be carried out using various chlorinating agents, often in glacial acetic acid, with precise temperature control to ensure the desired product is formed with minimal byproducts. The selection of specific reaction conditions, such as the addition of chlorine gas or other halogenating agents, is crucial for achieving high purity and yield, underscoring its role as a key organic synthesis intermediate.

Another noteworthy synthesis approach involves the use of trichloroisocyanuric acid as a chlorinating agent. This method has gained attention for its potential efficiency and convenience in certain laboratory and industrial settings. The consistent production of high-quality 4-amino-3,5-dichloroacetophenone is essential, particularly given its primary application as a pharmaceutical intermediate in the synthesis of drugs such as Clenbuterol.

As a leading supplier of chemical intermediates, Ningbo Inno Pharmchem Co., Ltd. places a strong emphasis on the quality and integrity of compounds like 4-Amino-3,5-dichloroacetophenone. We understand the importance of providing reliable chemical synthesis intermediates to our clients in the pharmaceutical, agrochemical, and materials science sectors. Our commitment to detailed chemical analysis and process optimization ensures that we deliver products that meet stringent specifications. For those looking to buy 4-amino-3,5-dichloroacetophenone, our expertise and dedication to quality make us an ideal partner.