The Chemical Profile of 2-Chloro-1,4-Naphthoquinone: A Key Intermediate
2-Chloro-1,4-naphthoquinone (CAS 1010-60-2) is a molecular entity characterized by a naphthalene core substituted with two ketone groups and a chlorine atom. Its chemical formula is C10H5ClO2, and its molecular weight is approximately 192.60 g/mol. This compound is typically presented as a yellow crystalline powder, a physical characteristic that aids in its identification and quality assessment. The chemical structure imparts specific reactivity, making it a valuable intermediate in various organic synthesis pathways, most notably in the pharmaceutical sector.
Understanding its physicochemical properties is crucial for its effective use. Its density is reported as 1.42 g/cm³, and it possesses a relatively high boiling point of 308°C at standard atmospheric pressure (760 mmHg). While specific data on its melting point can vary, its flash point is noted at 129.3°C, indicating a moderate flammability risk that requires appropriate handling procedures. The refractive index is 1.625, which is a characteristic optical property.
The purity of 2-Chloro-1,4-naphthoquinone is a critical specification, with industry standards typically requiring a minimum purity of 98%. Key impurities to monitor include naphthoquinonedichloride (max 1.0%) and total impurities (max 2.0%), along with a maximum loss on drying of 0.5%. These stringent specifications underscore its importance as a pharmaceutical intermediate, particularly in the synthesis of Atovaquone. The reliable production of such a compound necessitates rigorous quality control measures by manufacturers.
Storage conditions are also vital for maintaining the integrity of 2-Chloro-1,4-naphthoquinone. It should be stored in a cool, dry, and well-closed container, shielded from moisture and strong light or heat. By adhering to these guidelines and sourcing from reputable suppliers, companies can ensure they are utilizing a high-quality chemical that meets the demanding requirements of pharmaceutical synthesis. The consistent availability of this compound from manufacturers, especially those in China, supports the ongoing production of essential medicines.
Understanding its physicochemical properties is crucial for its effective use. Its density is reported as 1.42 g/cm³, and it possesses a relatively high boiling point of 308°C at standard atmospheric pressure (760 mmHg). While specific data on its melting point can vary, its flash point is noted at 129.3°C, indicating a moderate flammability risk that requires appropriate handling procedures. The refractive index is 1.625, which is a characteristic optical property.
The purity of 2-Chloro-1,4-naphthoquinone is a critical specification, with industry standards typically requiring a minimum purity of 98%. Key impurities to monitor include naphthoquinonedichloride (max 1.0%) and total impurities (max 2.0%), along with a maximum loss on drying of 0.5%. These stringent specifications underscore its importance as a pharmaceutical intermediate, particularly in the synthesis of Atovaquone. The reliable production of such a compound necessitates rigorous quality control measures by manufacturers.
Storage conditions are also vital for maintaining the integrity of 2-Chloro-1,4-naphthoquinone. It should be stored in a cool, dry, and well-closed container, shielded from moisture and strong light or heat. By adhering to these guidelines and sourcing from reputable suppliers, companies can ensure they are utilizing a high-quality chemical that meets the demanding requirements of pharmaceutical synthesis. The consistent availability of this compound from manufacturers, especially those in China, supports the ongoing production of essential medicines.
Perspectives & Insights
Alpha Spark Labs
“These stringent specifications underscore its importance as a pharmaceutical intermediate, particularly in the synthesis of Atovaquone.”
Future Pioneer 88
“The reliable production of such a compound necessitates rigorous quality control measures by manufacturers.”
Core Explorer Pro
“Storage conditions are also vital for maintaining the integrity of 2-Chloro-1,4-naphthoquinone.”