For chemists and researchers involved in organic synthesis, understanding the detailed chemical profile of intermediates is essential for successful project execution. 2-Methyl-5-nitropyridine (CAS: 21203-68-9) is a valuable pyridine derivative whose properties make it a key player in numerous synthetic routes. This article explores its critical characteristics, including physical properties, chemical reactivity, and insights into its synthesis.

The chemical name, 2-Methyl-5-nitropyridine, clearly defines its structure: a pyridine ring with a methyl group at the 2-position and a nitro group at the 5-position. Its molecular formula is C6H6N2O2, with a molecular weight of 138.12 g/mol. Physically, it is commonly described as a light brown solid, with a reported melting point of 112°C. This solid state at room temperature simplifies handling and storage for many applications. Its solubility is noted as being slightly soluble in water but soluble in common organic solvents like dichloromethane, which is typical for such organic molecules and aids in reaction setup and work-up procedures.

From a chemical reactivity standpoint, the nitro group on the pyridine ring is electron-withdrawing, influencing the reactivity of the ring system. This nitro group can be reduced to an amine, a critical step in many synthetic transformations, particularly in the preparation of pharmaceutical intermediates. The methyl group also offers a site for potential functionalization or can influence the steric and electronic properties of the molecule. Understanding these aspects is vital when you buy 2-Methyl-5-nitropyridine for specific synthetic goals.

The synthesis of 2-Methyl-5-nitropyridine often involves the modification of pyridine precursors. One common route starts with diethyl (5-nitro-pyridin-2-yl)-malonate, which is treated with sulfuric acid and heated. After neutralization and extraction, the desired product is obtained. This synthetic pathway underscores the importance of reliable chemical suppliers who can provide precursors and intermediates with consistent quality. When seeking to buy 2-Methyl-5-nitropyridine, verifying the purity (e.g., ≥99.0% HPLC) and consistency from a trusted organic synthesis intermediate manufacturer is crucial.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-quality 2-Methyl-5-nitropyridine to the global market. We offer detailed specifications and competitive pricing for this essential chemical. If you are interested in the CAS 21203-68-9 price or need to source this intermediate, please contact us. Our expertise ensures you receive a product that meets your demanding synthetic requirements.