Understanding the chemical and physical attributes of key intermediates is fundamental to their successful application in synthesis. 5-Chlorothiophene-2-Carboxylic Acid (CAS 24065-33-6), a prominent compound in pharmaceutical manufacturing, possesses a unique profile that makes it highly valuable. This cream-yellow powder, supplied by NINGBO INNO PHARMCHEM CO.,LTD., is integral to the creation of vital drugs like Rivaroxaban, and its properties dictate its efficacy and handling in industrial settings.

The molecular formula for 5-Chlorothiophene-2-Carboxylic Acid is C5H3ClO2S, with a molecular weight of approximately 162.59 g/mol. Its structure features a thiophene ring, a five-membered aromatic ring containing sulfur, substituted with a chlorine atom at the 5-position and a carboxylic acid group at the 2-position. This specific arrangement confers distinct reactivity and stability. The chlorine atom provides a site for nucleophilic substitution, while the carboxylic acid group can undergo esterification, amidation, and other common reactions, making it a versatile organic synthesis chemical intermediate.

Key physical properties are critical for process design and optimization. 5-Chlorothiophene-2-Carboxylic Acid typically presents as a cream-yellow to light yellow solid. Its melting point generally falls within the range of 148-156 °C, signifying its solid state under standard laboratory and industrial conditions. The reported boiling point is around 287.0±20.0 °C, indicating a compound that can withstand moderate heating during synthesis. Its solubility in common organic solvents like DMSO and methanol further enhances its utility in various reaction media. For manufacturers, understanding these properties is crucial for efficient handling, storage, and reaction design when producing this high purity thiophene carboxylic acid.

The industrial relevance of 5-Chlorothiophene-2-Carboxylic Acid is primarily anchored in its role as a crucial intermediate for Rivaroxaban. Rivaroxaban is a breakthrough anticoagulant, and its synthesis involves a multi-step process where this thiophene derivative plays an indispensable part. The quality of the 5-chlorothiophene-2-carboxylic acid directly influences the purity and yield of the final Active Pharmaceutical Ingredient (API). Therefore, sourcing from a reliable pharmaceutical intermediate chemical supplier like NINGBO INNO PHARMCHEM CO.,LTD. is essential for ensuring the efficacy and safety of the end product.

Beyond pharmaceuticals, the reactive nature of 5-Chlorothiophene-2-Carboxylic Acid makes it a valuable asset in broader organic synthesis. Chemists can utilize it as a starting material to construct more complex heterocyclic compounds, explore new catalytic systems, or develop novel functional materials. Its established role in the pharmaceutical industry also ensures a consistent demand, making it an attractive compound for chemical manufacturers. For those seeking to purchase this critical component, identifying a reputable 5-chlorothiophene-2-carboxylic acid manufacturer who can guarantee consistent quality is a strategic advantage.

In conclusion, the chemical and physical properties of 5-Chlorothiophene-2-Carboxylic Acid, including its reactive functional groups, melting point, and solubility, make it an exceptionally valuable intermediate in organic synthesis. Its critical role in the production of Rivaroxaban and its broader potential in chemical research highlight its significance in the industry. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing this compound with the highest standards of quality, supporting the advancements that drive modern chemistry and healthcare.