For chemists and product developers, a thorough understanding of a chemical intermediate's properties is fundamental to its successful application. 5-Fluoro-2-nitrotoluene (CAS 446-33-3) is a compound whose specific chemical and physical characteristics dictate its utility in various synthesis processes. As a key intermediate, its specifications are closely monitored by manufacturers and end-users alike.

Physical Characteristics of 5-Fluoro-2-nitrotoluene

5-Fluoro-2-nitrotoluene, with the molecular formula C7H6FNO2, has a molecular weight of approximately 155.13 g/mol. Its appearance is typically described as colorless to light yellow liquid. The melting point of this compound is noted at 28°C, indicating it can solidify at cooler ambient temperatures. Its boiling point is approximately 97-98°C when measured under reduced pressure (10 mmHg). These properties are critical for handling, storage, and reaction design. When considering purchasing this chemical, understanding these physical states and transitions is important for logistical planning and process optimization.

Key Chemical Properties and Reactivity

The chemical structure of 5-Fluoro-2-nitrotoluene features a toluene ring substituted with a fluorine atom and a nitro group. The fluorine atom, known for its electron-withdrawing effect, and the nitro group, also electron-withdrawing, influence the reactivity of the aromatic ring. These functional groups make it a valuable precursor in organic synthesis, enabling various electrophilic and nucleophilic substitution reactions, as well as reduction of the nitro group to an amine. Chemists often leverage these characteristics to build more complex molecules for pharmaceutical and agrochemical applications.

Industrial Specifications and Quality Control

When you buy 5-Fluoro-2-nitrotoluene, you’ll encounter various quality standards such as USP (United States Pharmacopeia), BP (British Pharmacopoeia), and FCC (Food Chemicals Codex), although its primary use is industrial, not in food or direct pharmaceutical formulation as a final product. Purity is a key specification, often quantified by Gas Chromatography (GC), with typical offerings including ≥95% or ≥98% purity. Manufacturers also provide data on density (around 1.272 g/mL at 25°C) and refractive index (n20/D 1.527), which serve as important quality control parameters. Understanding these specifications allows procurement managers and researchers to select the most appropriate grade for their specific synthesis needs.

In essence, the chemical profile of 5-Fluoro-2-nitrotoluene (CAS 446-33-3) provides essential information for its effective use in industrial applications. Manufacturers and suppliers emphasize these properties to ensure customers can confidently source and utilize this versatile intermediate in their chemical processes.