For chemists and researchers engaged in organic synthesis and peptide development, understanding the precise chemical properties of their starting materials is fundamental. H-D-Pro-NH2, also known as D-Proline Amide (CAS 62937-45-5), is a valuable chiral intermediate. This article details its key chemical characteristics and provides guidance on its proper handling to ensure optimal results in laboratory settings.

Key Chemical and Physical Properties of H-D-Pro-NH2

H-D-Pro-NH2 is characterized by its distinct chemical structure and physical attributes, making it suitable for a range of synthetic applications:

  • Molecular Formula: C5H10N2O
  • Molecular Weight: Approximately 114.15 g/mol
  • Appearance: Typically supplied as a white to off-white crystalline powder. The initial reference material describes it as a white crystal powder.
  • Melting Point: Reported in the range of 95-97°C. This relatively sharp melting point is indicative of good purity.
  • Solubility: While not explicitly detailed in all sources, similar amino acid derivatives are generally soluble in polar solvents like water and ethanol. Specific solubility data should be confirmed with the supplier.
  • Optical Activity: As a chiral molecule, H-D-Pro-NH2 exhibits optical rotation. Specific rotation values, such as +110±3° (c=2 in ethanol), are provided, confirming its D-configuration and enantiomeric purity.
  • Chemical Stability: Generally stable under recommended storage conditions. However, like most organic compounds, it should be protected from excessive heat, moisture, and incompatible materials.

Safe Handling and Storage Recommendations

To maintain the integrity of H-D-Pro-NH2 and ensure laboratory safety, adherence to proper handling and storage protocols is essential:

  • Storage Temperature: It is often recommended to store H-D-Pro-NH2 at refrigerated temperatures, typically around -15°C to -20°C, to preserve its stability and prevent degradation.
  • Handling Precautions: Always handle the chemical in a well-ventilated area or under a fume hood. Wear appropriate personal protective equipment (PPE), including gloves, safety glasses, and a lab coat. Avoid inhalation of dust and contact with skin and eyes.
  • Incompatible Materials: Keep away from strong oxidizing agents and strong acids, which could potentially react with the amide or amine functionalities.
  • Moisture Sensitivity: Although water content is usually specified as low (≤ 0.5%), it's advisable to keep the container tightly sealed to prevent moisture absorption, which can affect purity and assay.

Procurement Considerations for Researchers

When you need to buy H-D-Pro-NH2 for your research, procuring it from a reliable manufacturer or supplier is crucial. Look for suppliers who provide accurate chemical information and maintain strict quality control. Many suppliers offer D-Proline Amide in various quantities, from gram-scale for R&D to kilogram-scale for pilot production. Inquiring about the D-Proline Amide price and bulk purchase options can be beneficial for long-term projects.

By understanding and applying this information, researchers can effectively utilize H-D-Pro-NH2 in their synthetic endeavors, ensuring both successful experimental outcomes and a safe working environment.