Methyl 4-chloro-7-methoxyquinoline-6-carboxylate, identified by its CAS number 205448-66-4, is a compound of significant interest within the chemical and pharmaceutical research communities. Understanding its chemical profile—including its physical properties, molecular structure, and synthesis methods—is crucial for researchers and manufacturers who intend to buy Methyl 4-chloro-7-methoxyquinoline-6-carboxylate for their projects. As a dedicated supplier in China, we provide comprehensive information on this vital intermediate.

The compound typically presents as an off-white to yellow solid, a physical characteristic that is important for identification and quality assessment. Its melting point is reported to be above 125°C with decomposition, indicating its stability under moderate thermal conditions. The solubility in common solvents like DMSO and methanol is described as slight, which suggests that specific solvent systems or elevated temperatures might be required for effective dissolution in reaction mixtures. The molecular formula is C12H10ClNO3, with a molecular weight of approximately 251.67 g/mol. This detailed chemical makeup is fundamental for stoichiometry calculations and reaction planning.

The synthesis of Methyl 4-chloro-7-methoxyquinoline-6-carboxylate often involves the chlorination of a precursor such as Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate using reagents like thionyl chloride in the presence of dimethylformamide. This process, typically carried out under reflux conditions, yields the desired product with a specific purity, often around 95% or higher. Understanding these synthesis pathways is beneficial for researchers looking to replicate or optimize production, or for those interested in the upstream raw materials required. As a leading chemical intermediate provider, we offer this compound manufactured under controlled conditions to ensure high purity and consistent quality.

The applications of Methyl 4-chloro-7-methoxyquinoline-6-carboxylate are primarily centered around its utility as a building block in medicinal chemistry. It is instrumental in the synthesis of naphthamides that act as inhibitors of vascular endothelial growth factor (VEGF) receptor tyrosine kinase, playing a role in anti-cancer drug development. Additionally, it finds application in pharmaceutical preparations for treating infections, especially those related to burns. Researchers working in these advanced fields can rely on us for their supply. When you inquire about our CAS 205448-66-4 price, you are investing in a compound that supports cutting-edge pharmaceutical research.

In conclusion, the chemical profile of Methyl 4-chloro-7-methoxyquinoline-6-carboxylate is well-defined, offering clarity on its properties and synthesis. Its established applications make it a valuable intermediate for drug discovery and development. If your work requires this compound, consider us your trusted pharmaceutical intermediate manufacturer. We are committed to providing high-quality products and reliable service to support your scientific endeavors.