The Chemical Profile of Methyl 5-(2,4-Difluorophenyl)-4-Methoxy-1H-Pyrrole-3-Carboxylate: Properties and Applications
In the realm of pharmaceutical chemistry, understanding the detailed chemical profile of intermediates is crucial for successful synthesis and research applications. Methyl 5-(2,4-Difluorophenyl)-4-Methoxy-1H-Pyrrole-3-Carboxylate, identified by its CAS number 1902955-29-6, is a compound that exemplifies the importance of precise chemical characterization. Supplied by Nanjing Xinbell Pharmaceutical Technology Co., Ltd., this intermediate offers a unique set of properties that make it valuable across various stages of pharmaceutical development.
The chemical structure of Methyl 5-(2,4-Difluorophenyl)-4-Methoxy-1H-Pyrrole-3-Carboxylate features a difluorophenyl group attached to a methoxy-substituted pyrrole ring, with a methyl carboxylate functional group. This specific arrangement of atoms and functional groups dictates its reactivity and suitability for various synthetic transformations. The compound typically presents as a white to off-white powder, indicating a certain level of purity and solid-state form that is convenient for handling and further processing in synthesis laboratories. Its molecular formula is C13H11F2NO3, with a molecular weight of approximately 267.23 g/mol. These basic chemical identifiers are fundamental for any chemist working with the substance.
The primary application of Methyl 5-(2,4-Difluorophenyl)-4-Methoxy-1H-Pyrrole-3-Carboxylate is as a key intermediate in the synthesis of Fexuprazan. This drug, which is being investigated for its therapeutic effects, requires a complex synthetic pathway where this specific pyrrole derivative plays a pivotal role in constructing the final molecular architecture. The high purity of this intermediate, often exceeding 98%, is critical for ensuring the efficacy and safety of the resulting API, minimizing the presence of potentially harmful impurities.
Beyond its direct role in API synthesis, the compound also finds significant utility in pharmaceutical research. Medicinal chemists can leverage its distinct chemical scaffold to synthesize novel compounds, exploring variations in substitution patterns or functional groups to discover new drug candidates. Its use as an analytical standard for method development and validation is another critical application. By providing a pure, well-characterized sample, it enables the accurate identification and quantification of process-related impurities, supporting quality control and regulatory compliance efforts.
Nanjing Xinbell Pharmaceutical Technology Co., Ltd. offers this vital intermediate with certifications such as GMP, ISO 9001, and FDA compliance, underscoring a commitment to quality and regulatory adherence. The company also provides custom synthesis services, allowing researchers to obtain specific quantities or chemically modified versions of the intermediate to suit specialized project needs. This flexibility is instrumental in accelerating the pace of drug discovery and ensuring that the pharmaceutical industry has access to the high-quality chemical building blocks required for innovation.
In summary, Methyl 5-(2,4-Difluorophenyl)-4-Methoxy-1H-Pyrrole-3-Carboxylate is more than just a chemical compound; it is an enabling tool for pharmaceutical advancement, supporting everything from the synthesis of novel drugs to the rigorous analytical testing that guarantees their quality and safety.
Perspectives & Insights
Core Pioneer 24
“The high purity of this intermediate, often exceeding 98%, is critical for ensuring the efficacy and safety of the resulting API, minimizing the presence of potentially harmful impurities.”
Silicon Explorer X
“Beyond its direct role in API synthesis, the compound also finds significant utility in pharmaceutical research.”
Quantum Catalyst AI
“Medicinal chemists can leverage its distinct chemical scaffold to synthesize novel compounds, exploring variations in substitution patterns or functional groups to discover new drug candidates.”