The Chemical Properties and Applications of Boc-4-Methoxyphenylalanine
Understanding the chemical properties of key intermediates is fundamental to their successful application in synthesis. Boc-4-Methoxyphenylalanine (CAS 53267-93-9) is a prime example of a compound whose specific characteristics make it highly valuable in the pharmaceutical and chemical research sectors. Its composition as a protected amino acid derivative dictates its utility as a precise building block.
Chemically, Boc-4-Methoxyphenylalanine is known as (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-methoxyphenyl)propanoic acid. The most prominent feature is the tert-butoxycarbonyl (Boc) group, which serves as a protecting agent for the amine functionality. This protection is reversible, typically removed under mild acidic conditions, allowing for controlled deprotection and subsequent reactions. The presence of a methoxy group on the phenyl ring and the chiral center at the alpha-carbon further define its reactivity and stereochemical properties.
The physical properties are also significant for practical use. Data indicates a density of approximately 1.168 g/cm³, a high boiling point of 462ºC at 760 mmHg, and a flash point of 233.2ºC, suggesting good thermal stability. Its refractive index of 1.522 is another physical descriptor. Crucially, its specifications often include a high purity of ≥98%, with moisture content below 0.5% and impurities also below 0.5%. These stringent purity requirements are essential for its role as a pharmaceutical intermediate.
The applications of Boc-4-Methoxyphenylalanine are primarily centered around peptide synthesis and as a versatile intermediate in organic synthesis. In peptide synthesis, it allows for the sequential addition of amino acids, with the Boc group ensuring regioselectivity. This controlled assembly is critical for creating biologically active peptides used in therapeutics and research.
As a pharmaceutical intermediate, it is integrated into the synthesis pathways of various drugs. Its structure can be modified to yield compounds with desired pharmacological activities. The consistent quality and predictable chemical behavior of Boc-4-Methoxyphenylalanine from reliable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. are key to successful pharmaceutical development. For anyone involved in advanced chemical synthesis, grasping the chemical and physical attributes of this compound is essential for optimizing experimental designs and ensuring reproducible results.
Chemically, Boc-4-Methoxyphenylalanine is known as (2S)-2-[(tert-Butoxycarbonyl)amino]-3-(4-methoxyphenyl)propanoic acid. The most prominent feature is the tert-butoxycarbonyl (Boc) group, which serves as a protecting agent for the amine functionality. This protection is reversible, typically removed under mild acidic conditions, allowing for controlled deprotection and subsequent reactions. The presence of a methoxy group on the phenyl ring and the chiral center at the alpha-carbon further define its reactivity and stereochemical properties.
The physical properties are also significant for practical use. Data indicates a density of approximately 1.168 g/cm³, a high boiling point of 462ºC at 760 mmHg, and a flash point of 233.2ºC, suggesting good thermal stability. Its refractive index of 1.522 is another physical descriptor. Crucially, its specifications often include a high purity of ≥98%, with moisture content below 0.5% and impurities also below 0.5%. These stringent purity requirements are essential for its role as a pharmaceutical intermediate.
The applications of Boc-4-Methoxyphenylalanine are primarily centered around peptide synthesis and as a versatile intermediate in organic synthesis. In peptide synthesis, it allows for the sequential addition of amino acids, with the Boc group ensuring regioselectivity. This controlled assembly is critical for creating biologically active peptides used in therapeutics and research.
As a pharmaceutical intermediate, it is integrated into the synthesis pathways of various drugs. Its structure can be modified to yield compounds with desired pharmacological activities. The consistent quality and predictable chemical behavior of Boc-4-Methoxyphenylalanine from reliable manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. are key to successful pharmaceutical development. For anyone involved in advanced chemical synthesis, grasping the chemical and physical attributes of this compound is essential for optimizing experimental designs and ensuring reproducible results.
Perspectives & Insights
Bio Analyst 88
“Its structure can be modified to yield compounds with desired pharmacological activities.”
Nano Seeker Pro
“The consistent quality and predictable chemical behavior of Boc-4-Methoxyphenylalanine from reliable manufacturers like NINGBO INNO PHARMCHEM CO.”
Data Reader 7
“For anyone involved in advanced chemical synthesis, grasping the chemical and physical attributes of this compound is essential for optimizing experimental designs and ensuring reproducible results.”