Cyclopropyl Acetylene (CAS 6746-94-7), also known as ethynylcyclopropane, is a chemical compound that requires careful consideration of its properties and safe handling practices. As a vital intermediate in organic synthesis, particularly within the pharmaceutical industry, understanding these aspects is crucial for researchers and manufacturers alike.

From a chemical perspective, Cyclopropyl Acetylene is characterized by its molecular formula C5H6 and a molecular weight of approximately 66.10 g/mol. It typically presents as a clear, colorless to light yellow liquid. Its physical properties, such as a boiling point around 79-80°C and a flash point of -5°F (-18°C), clearly indicate its highly flammable nature. This flammability is a primary safety concern, necessitating storage and handling in well-ventilated areas, away from ignition sources, and in approved containers. Many suppliers, including those in China who are significant manufacturers, recommend storage at specific temperatures, often between 0-8°C, to maintain stability and quality.

The reactivity of Cyclopropyl Acetylene stems from its terminal alkyne group, which readily participates in various chemical transformations. This includes its use in cycloaddition reactions and as a building block in metal-catalyzed coupling reactions. These properties make it invaluable for creating complex organic molecules, including pharmaceutical intermediates. For example, its incorporation into drug synthesis pathways, such as for certain antiretroviral drugs, highlights its significant contribution to medicinal chemistry.

When you are looking to purchase Cyclopropyl Acetylene, whether for laboratory research or industrial-scale production, it is imperative to source from reputable suppliers who provide comprehensive Safety Data Sheets (SDS). These documents detail the hazards associated with the chemical, recommended personal protective equipment (PPE), first-aid measures, and spill-handling procedures. Adherence to GHS hazard statements, such as warnings for flammability and potential health effects (e.g., skin irritation, serious eye damage), is critical.

In summary, while Cyclopropyl Acetylene (CAS 6746-94-7) is a highly useful chemical intermediate, its inherent flammability and reactivity demand strict adherence to safety protocols. By prioritizing quality sourcing from reliable manufacturers and understanding its chemical properties, users can effectively and safely leverage this compound in their innovative synthesis projects.