For research and development scientists, understanding the precise chemical properties and reactivity of intermediates is crucial for successful synthesis. 5-Bromo-2-fluorobenzonitrile (CAS 179897-89-3) is a prime example of such a compound, offering a unique combination of functional groups that unlock diverse synthetic possibilities. This article delves into its key characteristics and application areas, emphasizing its value to the scientific community.

The molecular structure of 5-Bromo-2-fluorobenzonitrile, C7H3BrFN, is central to its utility. The presence of both a bromine atom and a fluorine atom on the benzonitrile ring creates specific electronic and steric effects. The electron-withdrawing nature of the cyano group and the fluorine atom makes the aromatic ring electron-deficient, enhancing its susceptibility to nucleophilic attack at certain positions. Conversely, the bromine atom serves as an excellent leaving group, particularly in transition metal-catalyzed cross-coupling reactions. This dual functionality makes it a highly versatile building block.

Key physical properties, such as its appearance as a white to off-white crystalline powder, and a melting point typically ranging from 76-81°C, are important for handling and reaction setup. Its solubility in common organic solvents like dichloromethane (DCM), tetrahydrofuran (THF), and dimethylformamide (DMF) further facilitates its integration into various reaction protocols.

In terms of synthesis applications, 5-Bromo-2-fluorobenzonitrile is widely employed in the construction of complex organic molecules. Its participation in Suzuki-Miyaura couplings allows for the introduction of aryl or vinyl groups, extending carbon frameworks. Similarly, Buchwald-Hartwig amination enables the formation of carbon-nitrogen bonds, essential for creating amide or amine functionalities found in many pharmaceuticals and agrochemicals. The compound is also a valuable precursor for heterocycle synthesis, a critical area in medicinal chemistry.

Scientists aiming to buy 5-Bromo-2-fluorobenzonitrile for their research will find its well-defined reactivity predictable and controllable. When sourcing this intermediate, looking for a reliable 5-Bromo-2-fluorobenzonitrile supplier who can provide high purity material is paramount. The consistency in quality ensures reproducible results, which is vital for any research project or process development.

The ability to efficiently synthesize complex molecules using intermediates like 5-Bromo-2-fluorobenzonitrile significantly accelerates the pace of discovery in fields ranging from drug development to novel material creation. By understanding and leveraging its chemical properties, researchers can design more efficient synthetic routes and explore new chemical space. For those in need, contacting a leading 5-Bromo-2-fluorobenzonitrile manufacturer in China can ensure a steady supply of this critical research tool.