Understanding the precise chemical properties and synthesis routes of key intermediates is fundamental for chemists and formulators in the B2B sector. 1-(2-Hydroxyethyl)-4-methylpiperazine, identified by CAS number 5464-12-0, is a prime example of such a crucial compound, widely utilized in organic synthesis and pharmaceutical manufacturing. As a leading manufacturer and supplier, we aim to provide comprehensive details on this valuable chemical.

Detailed Chemical and Physical Properties

1-(2-Hydroxyethyl)-4-methylpiperazine possesses a molecular formula of C7H16N2O and a molecular weight of 144.21500. It is typically supplied as a white powder, with a defined melting point range of 39-41°C. The compound exhibits a density of approximately 1.003 g/cm³. Its solubility in common solvents like methanol is notable. The presence of both a tertiary amine within the piperazine ring and a primary alcohol group in the side chain grants it a versatile reactivity profile. Its flash point is recorded at 106.1°C, indicating moderate flammability, and it is generally stored in a cool, dry, well-ventilated area away from incompatible substances.

Synthesis Pathways Explained

The production of 1-(2-Hydroxyethyl)-4-methylpiperazine often involves the reaction of N-methylpiperazine with a 2-haloethanol, such as 2-bromoethanol or 2-chloroethanol, in the presence of a base like potassium carbonate. The reaction is typically carried out in a solvent such as ethanol under reflux conditions for several hours. Following the reaction, purification steps involve filtration to remove inorganic salts and solvent removal. Yields and purity can be optimized through careful control of reaction parameters, temperature, and reagent ratios. We employ advanced synthesis techniques to ensure high purity (≥97.0%) and minimize impurities for our customers who buy this intermediate.

Why Purity Matters for Your Applications

For any application in organic synthesis or pharmaceutical intermediate production, the purity of 1-(2-Hydroxyethyl)-4-methylpiperazine is critical. Impurities can lead to unwanted side reactions, reduced yields, and potentially compromise the efficacy or safety of the final product. As a manufacturer committed to excellence, we meticulously monitor our synthesis processes. This dedication ensures that researchers and manufacturers can confidently purchase our product, knowing they are receiving a reliable and high-quality chemical intermediate. We encourage you to inquire about our pricing and bulk availability to support your ongoing projects.