For researchers and chemists involved in advanced synthesis and biochemical studies, a thorough understanding of chemical properties and synthesis routes for key intermediates is invaluable. 2'-Deoxyguanosine Monohydrate (CAS 961-07-9) is one such compound, a vital deoxynucleoside widely used in pharmaceutical development and molecular biology. Let's delve into its chemical characteristics and common synthesis approaches.

2'-Deoxyguanosine Monohydrate, with the molecular formula C10H13N5O4, is a derivative of guanine, a purine base, attached to a deoxyribose sugar. Its molecular weight is approximately 285.25700. The monohydrate form indicates the presence of one molecule of water per molecule of deoxyguanosine. Key physical properties include its appearance as a white powder, making it easy to handle and weigh accurately for precise laboratory applications. While its density is 2.085 g/cm³, specific solubility data is critical for formulation scientists when planning reaction conditions.

The synthesis of 2'-Deoxyguanosine Monohydrate typically involves the glycosylation of a suitably protected guanine derivative with a protected deoxyribose sugar. Various chemical strategies exist, often employing coupling reagents and protecting group manipulations to ensure regioselectivity and stereoselectivity, yielding the desired beta-anomer. Efficient synthesis pathways aim for high yields and purity, minimizing the need for extensive purification steps. Researchers looking to buy this compound often seek suppliers who master these complex synthesis protocols.

The compound's stability under various conditions is also an important consideration. As a pharmaceutical intermediate, its shelf-life and resistance to degradation during storage and handling are crucial. Manufacturers must ensure appropriate packaging and storage recommendations are provided. Understanding its reactivity, particularly the functional groups available for further chemical modification, is key for scientists designing new molecules. For example, the amino and hydroxyl groups can be sites for further derivatization.

When procuring 2'-Deoxyguanosine Monohydrate, particularly for large-scale projects, engaging with manufacturers who can guarantee high purity (e.g., 99%) and consistent batch-to-batch quality is paramount. A reliable supplier will provide comprehensive technical data, including melting point, spectroscopic data (NMR, MS), and HPLC analysis results, which are essential for quality assurance. For those in China or sourcing from China, understanding the local chemical manufacturing landscape can help identify top-tier producers.

In summary, the chemical properties and efficient synthesis of 2'-Deoxyguanosine Monohydrate underscore its significance as a foundational element in pharmaceutical research. By understanding these aspects, scientists and procurement managers can make informed decisions when purchasing this vital chemical intermediate.