Understanding the fundamental chemical properties and synthesis routes of key chemical compounds is essential for any professional in the B2B chemical and pharmaceutical sectors. cis-4-Hydroxy-L-proline (CAS 618-27-9) is one such compound, valued for its unique structure and broad applications. As a dedicated manufacturer and supplier of high-grade fine chemicals and pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is pleased to share insights into this important molecule.

cis-4-Hydroxy-L-proline is characterized by its white to beige powder appearance. Its chemical formula is C5H9NO3, with a molecular weight of 131.13 g/mol. A significant property is its high melting point, typically around 257 °C (with decomposition), indicating its thermal stability under normal storage conditions. The compound is soluble in water, which is a common and often advantageous characteristic for many synthetic and biochemical applications. The specific optical rotation (alpha) is approximately -59º, confirming its chiral nature and specific stereoisomeric configuration.

Industrially, the production of cis-4-Hydroxy-L-proline often involves biotechnological methods. Microorganisms capable of producing proline hydroxylase enzymes have been utilized to catalyze the hydroxylation of proline, leading to the formation of hydroxyproline isomers. This enzymatic approach allows for efficient and stereoselective synthesis, producing the desired cis-4-isomer. While chemical synthesis routes also exist, enzymatic methods are often favored for their specificity and environmental benefits when producing chiral molecules like this pharmaceutical intermediate.

The importance of cis-4-Hydroxy-L-proline lies in its role as a chiral building block. Its structure is crucial for the synthesis of complex organic molecules, especially in the pharmaceutical industry. It serves as a precursor for various Active Pharmaceutical Ingredients (APIs) and is researched for its potential therapeutic benefits, including its ability to inhibit collagen synthesis and its possible role in anticancer therapies. When you purchase this compound, understanding its chemical properties is key to optimizing its use in your synthesis or research.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing access to high-quality cis-4-Hydroxy-L-proline. Our rigorous quality control ensures that every batch meets the required specifications, making us a reliable supplier for your needs. We understand that competitive price is a significant factor for our B2B clients, and we strive to offer cost-effective solutions without compromising on quality. If you are looking to source this valuable intermediate, consider partnering with us. Contact us today to obtain a quote or to learn more about our manufacturing capabilities and how we can support your ongoing projects.