Ethyl 4,4-difluoro-3-oxobutanoate (CAS 352-24-9) is a fascinating organic compound that owes its utility to a unique combination of chemical properties and a well-defined synthesis route. As a difluorinated beta-keto ester, it possesses distinct reactivity that makes it invaluable as an intermediate in various sophisticated chemical syntheses. Understanding these chemical characteristics is crucial for R&D scientists aiming to leverage its potential in pharmaceutical, agrochemical, and specialty chemical applications.

Chemically, Ethyl 4,4-difluoro-3-oxobutanoate features an ester group, a ketone carbonyl, and two fluorine atoms attached to the alpha-carbon adjacent to the ketone. This specific arrangement imparts several key properties. The fluorine atoms are highly electronegative, significantly influencing the electron density distribution within the molecule. This electron-withdrawing effect can increase the acidity of any alpha-hydrogens (though in this case, the alpha-carbon to the ester is also substituted), and it activates the ketone carbonyl towards nucleophilic attack. The presence of these fluorine atoms also contributes to increased lipophilicity and metabolic stability in molecules derived from this intermediate, properties highly sought after in drug design.

The physical properties further define its handling and application. It is typically described as a colorless to almost colorless clear liquid with a relatively low melting point of -46°C, suggesting it remains liquid under most standard laboratory conditions. Its boiling point is around 162°C, and it possesses a density of 1.61 g/cm³. A flash point of 68°C classifies it as a flammable liquid, necessitating appropriate handling and storage precautions. These attributes are consistent with a moderately volatile organic compound.

The synthesis of Ethyl 4,4-difluoro-3-oxobutanoate can be achieved through various routes, with one common method involving the reaction of ethyl difluoroacetate with ethyl acetate under basic conditions. This Claisen condensation-type reaction allows for the formation of the beta-keto ester structure. The precise reaction conditions, choice of base, and purification steps are critical to achieving high yields and the desired purity (typically ≥ 99.0%). Manufacturers specializing in fine chemical intermediates often optimize these synthesis pathways to ensure consistent quality and competitive pricing.

For chemists and researchers, exploring the reactivity of Ethyl 4,4-difluoro-3-oxobutanoate opens doors to a multitude of synthetic possibilities. It can undergo reactions such as alkylation, acylation, condensation, and cyclization, enabling the construction of complex molecular architectures. The ability to purchase this compound from reliable manufacturers and suppliers in China, with assured purity and competitive pricing, significantly facilitates its use in both academic research and industrial-scale production. Understanding its chemical foundation is the first step to unlocking its full synthetic potential.