The Chemical Synthesis of 2-Amino-6-fluoro-N-phenylbenzamide: Insights from NINGBO INNO PHARMCHEM CO.,LTD.
The world of organic chemistry is a fascinating realm of molecular construction, where precise reactions lead to compounds with profound impacts on human health. 2-Amino-6-fluoro-N-phenylbenzamide (CAS 1417456-04-2) stands out as a vital intermediate in this domain, particularly for the pharmaceutical sector. At NINGBO INNO PHARMCHEM CO.,LTD., we delve into the intricacies of its chemical synthesis, highlighting its importance in producing advanced therapeutic agents.
The molecular structure of 2-amino-6-fluoro-N-phenylbenzamide, with its C13H11FN2O formula, is designed for specific reactivity and incorporation into larger molecular frameworks. Typically synthesized through multi-step processes, common routes involve amidation and reduction reactions. For instance, starting from a suitably substituted benzoic acid derivative, amide bond formation with aniline is a key step, followed by the reduction of a nitro group to yield the desired amino functionality. Optimization of these synthetic routes is crucial for maximizing yield and purity, especially when scaling up production.
The presence of the fluorine atom at the 6-position and the amino group at the 2-position on the benzamide ring are critical structural elements. These features often contribute to enhanced metabolic stability, altered electronic properties, and specific binding interactions within biological targets. This makes 2-amino-6-fluoro-N-phenylbenzamide an indispensable component in the synthesis of Idelalisib, a targeted cancer therapy. For pharmaceutical companies, securing a reliable supply of this intermediate with consistent quality is paramount.
NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to advancing the field by offering high-quality pharmaceutical intermediates. Our expertise in chemical synthesis allows us to produce compounds like 2-amino-6-fluoro-N-phenylbenzamide with the necessary precision and purity required by the industry. We understand that the performance of the final drug product is directly linked to the quality of its precursors.
The search for efficient and scalable synthetic methods for such intermediates is an ongoing endeavor in chemical research. Factors such as reaction conditions, catalyst selection, and purification techniques are meticulously optimized. For example, the choice of reducing agent and conditions can significantly influence the yield and purity of the amino group formation, minimizing undesired side products. This attention to detail is what sets leading 2-amino-6-fluoro-N-phenylbenzamide suppliers apart.
In summary, 2-amino-6-fluoro-N-phenylbenzamide exemplifies the critical role that well-crafted chemical intermediates play in modern medicine. NINGBO INNO PHARMCHEM CO.,LTD. is proud to contribute to this vital sector by providing high-purity compounds that empower drug discovery and manufacturing. Our commitment to excellence in chemical synthesis ensures that our partners have access to the essential building blocks for creating tomorrow's life-saving treatments.
Perspectives & Insights
Alpha Spark Labs
“For instance, starting from a suitably substituted benzoic acid derivative, amide bond formation with aniline is a key step, followed by the reduction of a nitro group to yield the desired amino functionality.”
Future Pioneer 88
“Optimization of these synthetic routes is crucial for maximizing yield and purity, especially when scaling up production.”
Core Explorer Pro
“The presence of the fluorine atom at the 6-position and the amino group at the 2-position on the benzamide ring are critical structural elements.”