The Chemical Synthesis of 6-Hydroxy-2H-benzofuran-3-one: A Look at Key Methods
The effective utilization of chemical compounds often hinges on understanding their synthesis pathways. For 6-Hydroxy-2H-benzofuran-3-one (CAS 6272-26-0), a compound crucial for various industrial applications, particularly as a pharmaceutical intermediate, its synthesis is a topic of significant interest. NINGBO INNO PHARMCHEM CO.,LTD. specializes in the production of this compound and offers insights into its common synthesis methods.
One prominent method for the synthesis of 6-Hydroxy-2H-benzofuran-3-one involves the reaction of 6-acetoxy-benzofuran-3-ol. This process is often carried out using neutral alumina as a reagent in neat conditions, frequently enhanced by microwave irradiation to achieve high yields, reportedly as high as 91%. Another noted reaction involves the condensation of 6-hydroxy-2,3-dihydrobenzofuran-3-one with 4-hydroxy-benzaldehyde in acetic acid and concentrated aqueous hydrochloric acid at approximately 60°C, yielding a product with a reported field of 75.2%.
As a dedicated supplier of fine chemicals, NINGBO INNO PHARMCHEM CO.,LTD. leverages advanced chemical engineering and deep knowledge of organic synthesis to produce high-purity 6-Hydroxy-2H-benzofuran-3-one. Our manufacturing capabilities are designed to ensure consistent product quality and scalability, meeting the diverse needs of our clients. Understanding the intricate chemical properties of CAS 6272-26-0 is fundamental to our production process, allowing us to optimize reaction conditions and purification techniques.
For businesses looking to buy 6-Hydroxy-2H-benzofuran-3-one online, choosing a manufacturer with a proven track record in synthesis is crucial. NINGBO INNO PHARMCHEM CO.,LTD. is committed to excellence, ensuring that our products contribute positively to our clients' research and development endeavors. Our expertise in the precise synthesis of 6-Hydroxy-2H-benzofuran-3-one translates into reliable intermediates for the global market.
In summary, the synthesis of 6-Hydroxy-2H-benzofuran-3-one is a testament to the power of organic chemistry. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to mastering these synthesis routes to provide the market with high-quality chemical intermediates, solidifying our position as a leading pharmaceutical intermediates supplier.
Perspectives & Insights
Core Pioneer 24
“This process is often carried out using neutral alumina as a reagent in neat conditions, frequently enhanced by microwave irradiation to achieve high yields, reportedly as high as 91%.”
Silicon Explorer X
“Another noted reaction involves the condensation of 6-hydroxy-2,3-dihydrobenzofuran-3-one with 4-hydroxy-benzaldehyde in acetic acid and concentrated aqueous hydrochloric acid at approximately 60°C, yielding a product with a reported field of 75.”
Quantum Catalyst AI
“leverages advanced chemical engineering and deep knowledge of organic synthesis to produce high-purity 6-Hydroxy-2H-benzofuran-3-one.”