For organic chemists and R&D professionals, a deep understanding of the synthesis and properties of key chemical intermediates is fundamental to designing efficient and successful reaction pathways. 1-Methyl-1H-pyrazol-3-amine (CAS 1904-31-0) is a prime example of such a molecule, serving as a versatile building block in diverse synthetic endeavors, particularly in the pharmaceutical and agrochemical sectors. Exploring how to purchase this compound from reliable sources often begins with understanding its inherent chemistry.

The molecular structure of 1-Methyl-1H-pyrazol-3-amine features a five-membered heterocyclic ring, the pyrazole, which contains two adjacent nitrogen atoms. One nitrogen is substituted with a methyl group, and the ring is further functionalized with an amine group at the third position. This arrangement confers specific reactivity, making it an excellent nucleophile and a substrate for various electrophilic aromatic substitution reactions. The presence of the amine group allows for straightforward derivatization through acylation, alkylation, and other reactions, which are crucial for building more complex molecular architectures.

While specific synthesis routes can vary, a common approach to preparing such pyrazole derivatives involves cyclization reactions. For 1-Methyl-1H-pyrazol-3-amine, this might entail reactions utilizing precursors that can form the pyrazole ring, followed by functional group installation or modification. Information from chemical databases indicates that its preparation can involve various established organic synthesis techniques. Manufacturers specializing in fine chemicals often optimize these processes to achieve high yields and purity for commercial supply.

Key physical properties of 1-Methyl-1H-pyrazol-3-amine include its liquid state at room temperature and a characteristic color that can range from clear to light orange or yellow. Its boiling point, typically around 93-94°C at reduced pressure (0.5 mmHg), and density (around 1.12 g/ml) are important parameters for handling and reaction design. The compound is also noted as being air-sensitive, suggesting that proper storage conditions, such as under an inert atmosphere (nitrogen or argon) and at cool temperatures (2-8°C), are necessary to maintain its integrity and reactivity. Buyers should confirm these specifications with their chosen supplier when they intend to purchase.

The utility of 1-Methyl-1H-pyrazol-3-amine extends to its role as a precursor for further transformations. For example, the amine group can be diazotized and coupled, or it can serve as a handle for building more elaborate heterocyclic systems, which are prevalent in many drug molecules and agrochemicals. Understanding these reaction possibilities allows chemists to effectively plan their synthesis and source the necessary intermediates.

In conclusion, delving into the chemistry of 1-Methyl-1H-pyrazol-3-amine reveals its significance as a versatile intermediate. For researchers and manufacturers looking to buy this compound, appreciating its synthesis and properties ensures informed procurement decisions, enabling the development of innovative products across the chemical industry. Partnering with reputable chemical manufacturers and suppliers for this essential material is a cornerstone of successful chemical R&D.