3-Bromofluorobenzene (CAS 1073-06-9) is a halogenated aromatic hydrocarbon that plays a significant role as a versatile intermediate in modern chemical synthesis. Its unique combination of a bromine atom and a fluorine atom on the meta positions of a benzene ring imparts specific reactivity and properties, making it invaluable for chemists engaged in drug discovery, agrochemical development, and materials science. Understanding its chemical characteristics and synthesis pathways is key for scientists and product formulators.

The chemical structure of 3-Bromofluorobenzene (C6H4BrF) features a molecular weight of approximately 175.00 g/mol. It typically presents as a clear, colorless to light yellow liquid with a distinct aromatic odor. Its physical properties, such as a melting point around -8 °C and a boiling point of approximately 147-151 °C, make it manageable under standard laboratory and industrial conditions. The presence of the electron-withdrawing fluorine atom and the larger bromine atom influences the electron density of the benzene ring, directing electrophilic aromatic substitution and facilitating various coupling reactions.

Several synthetic routes can lead to 3-Bromofluorobenzene. One common approach involves the Sandmeyer reaction, starting from 3-fluoroaniline. Diazotization of 3-fluoroaniline followed by treatment with copper(I) bromide can yield the desired product. Another method might involve the directed ortho-metalation of fluorobenzene followed by bromination. More advanced methods may also be employed, often starting from other halogenated or functionalized benzene derivatives. Researchers and manufacturers continually seek more efficient, cost-effective, and environmentally friendly synthesis pathways to produce this important intermediate. Those looking to buy can often inquire about specific synthesis methods or purity levels directly from a knowledgeable supplier.

The applications of 3-Bromofluorobenzene are extensive. As a pharmaceutical intermediate, it is crucial for building complex drug molecules. For example, it can be a precursor in the synthesis of certain antidepressants, anti-inflammatory drugs, or antiviral agents. In the agrochemical sector, it serves as a building block for herbicides and insecticides, where the halogen substituents can enhance bioactivity and persistence. Its utility extends to materials science, where it can be incorporated into organic electronic components or liquid crystal displays, contributing to desired electronic and optical properties. For scientists in these fields, the availability of high-purity 3-Bromofluorobenzene from a reliable manufacturer is paramount to their research and product development efforts.

When considering the purchase of 3-Bromofluorobenzene, scientists and formulators should always verify the CAS number (1073-06-9) and purity specifications. Engaging with manufacturers or distributors that provide detailed technical data and support can significantly streamline the procurement process. Understanding the chemistry behind this versatile molecule empowers users to make informed decisions and leverage its potential in their innovative projects.