The development of advanced pharmaceuticals like Apixaban is a testament to the power of organic chemistry and precise synthesis. At the heart of producing such life-saving drugs are the chemical intermediates that form the structural backbone of the final molecule. This article explores the chemistry of Apixaban synthesis, focusing on a pivotal intermediate: 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one (CAS 545445-44-1). Understanding the role and properties of such intermediates is crucial for anyone involved in pharmaceutical development and chemical manufacturing.

Apixaban, known for its role as a direct oral anticoagulant, functions by selectively inhibiting Factor Xa. This inhibition is key to preventing blood clots and reducing the risk of stroke and systemic embolism. The molecule's intricate structure is built through a series of carefully controlled chemical reactions, where intermediates serve as the essential building blocks. 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one represents a significant step in this synthetic pathway, bringing together key functional groups required for the final Apixaban structure.

From a chemical perspective, this intermediate is characterized by its specific molecular formula (C20H25N3O3) and molecular weight (355.43). Its physical appearance as a light beige solid, with a purity typically exceeding 98.0%, underscores its suitability for pharmaceutical applications. NINGBO INNO PHARMCHEM CO.,LTD. specializes in the production of such high-quality intermediates, ensuring that our clients receive materials that meet demanding specifications. Our expertise as a manufacturer in China allows us to provide reliable and consistent quality, supporting the complex needs of pharmaceutical research and production.

The synthesis often involves coupling reactions and cyclizations, where the precise structure of 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one is critical. Its morpholine and piperidinone moieties, along with the dihydropyridinone core, are essential structural elements that are carried through to the final Apixaban molecule. The reliable supply of this intermediate from manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. is crucial for the commercial viability and accessibility of Apixaban. By understanding the chemistry involved, pharmaceutical companies can better appreciate the value of partnering with suppliers committed to chemical excellence.

For businesses looking to source Apixaban intermediates, NINGBO INNO PHARMCHEM CO.,LTD. offers a direct route to high-quality, reliably produced compounds. We are dedicated to supporting the pharmaceutical industry by providing the essential chemical components that enable the creation of vital medications.