The Chemistry Behind Apixaban: Understanding Key Intermediates
Apixaban, a highly effective Factor Xa inhibitor, has become a cornerstone in the prevention and treatment of thromboembolic events. Its journey from raw materials to a finished pharmaceutical product involves intricate chemical transformations, with key intermediates serving as vital waypoints. One such critical intermediate is 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one (CAS 503615-03-0). Understanding its chemical nature and significance is essential for anyone involved in API manufacturing.
The synthesis of Apixaban is a multi-step process, and 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one represents a significant structural component that is built upon and further functionalized. This specific intermediate contains a morpholine ring and a nitrophenyl group attached to a dihydropyridinone core, which are all structural motifs essential for the final drug's biological activity. The precise arrangement and high purity of these functional groups within the intermediate are paramount for the success of subsequent reactions in the Apixaban synthesis pathway.
For manufacturers specializing in pharmaceutical intermediates, like ourselves, producing 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one to exact specifications is a core competency. Our commitment to quality assurance means that each batch undergoes stringent testing to confirm its identity and purity. We aim to provide material that not only conforms to the structure but also meets high purity standards, typically 98% or greater, ensuring that our clients can buy with confidence for their demanding API production needs. This focus on quality reduces the likelihood of costly errors and delays in the downstream manufacturing process.
The availability of reliable suppliers for intermediates like this is crucial for the global pharmaceutical supply chain. We serve as a key manufacturer in China, dedicated to providing consistent access to this vital chemical. Whether you are a large-scale pharmaceutical producer or a research and development laboratory, understanding the chemistry behind your raw materials is key. We welcome inquiries for 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one, offering competitive prices and a stable supply to support the continuous production of Apixaban and related research efforts.
By ensuring the quality and availability of key intermediates, we contribute to the broader goal of making life-saving medications accessible to patients worldwide. Explore how our high-purity Apixaban intermediate can streamline your manufacturing processes and enhance your product's integrity.
Perspectives & Insights
Logic Thinker AI
“The precise arrangement and high purity of these functional groups within the intermediate are paramount for the success of subsequent reactions in the Apixaban synthesis pathway.”
Molecule Spark 2025
“For manufacturers specializing in pharmaceutical intermediates, like ourselves, producing 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one to exact specifications is a core competency.”
Alpha Pioneer 01
“Our commitment to quality assurance means that each batch undergoes stringent testing to confirm its identity and purity.”