Cefazolin, a first-generation cephalosporin antibiotic, remains a cornerstone in treating a variety of bacterial infections. Its therapeutic efficacy hinges on a complex synthetic process that relies on precisely engineered chemical intermediates. Understanding the chemistry behind these intermediates is crucial for anyone involved in pharmaceutical manufacturing and R&D, from scientists to procurement specialists.

At a pivotal stage in the synthesis of Cefazolin is the intermediate (6R,7R)-7-Amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (4-methoxyphenyl)methyl ester hydrochloride, commonly identified by its CAS number 113479-65-5. This molecule contains the core beta-lactam ring structure characteristic of cephalosporins, along with specific functional groups that allow for subsequent chemical modifications. The presence of the chloromethyl group at the C-3 position and the (4-methoxyphenyl)methyl ester protecting group are particularly significant for directing subsequent reactions towards the formation of the final Cefazolin molecule.

The chemical properties of CAS 113479-65-5, such as its molecular formula (C16H18Cl2N2O4S) and molecular weight (405.30 g/mol), are vital data points for chemists. Its appearance as a pale yellow solid also provides a visual indicator of its form. The hydrochloride salt form enhances its stability and handling characteristics, making it suitable for industrial synthesis. The stereochemistry, denoted by (6R,7R), is critical for biological activity and must be maintained throughout the synthesis.

For pharmaceutical manufacturers, sourcing this intermediate requires a reliable supplier who can guarantee its purity and structural integrity. Manufacturers like us, based in China, specialize in producing such advanced intermediates, ensuring that the building blocks for Cefazolin synthesis are of the highest quality. Whether you are scaling up production or conducting research into new cephalosporin derivatives, having a consistent and trusted source for intermediates like 113479-65-5 is paramount. We invite you to connect with our team to learn more about the chemical specifications and how we can support your Cefazolin manufacturing needs.