Diethyl Malonate (DEM), chemical formula C7H12O4 and CAS number 105-53-3, is a diester derived from malonic acid. Its chemical structure, featuring active methylene hydrogens situated between two ester groups, makes it a highly reactive and versatile compound widely utilized in organic synthesis. Understanding its chemistry is key to appreciating its extensive applications.

The synthesis of Diethyl Malonate typically involves the esterification of malonic acid with ethanol, often using an acid catalyst. Alternatively, it can be prepared from chloroacetic acid via cyanoacetic acid. This process yields a colorless, transparent liquid with a faint, pleasant, aromatic odor, which naturally occurs in some fruits, contributing to their aroma profile.

The reactivity of Diethyl Malonate lies in the acidity of its methylene protons. These protons can be easily removed by a base, forming a carbanion which is resonance-stabilized. This nucleophilic carbanion can then readily react with various electrophiles, enabling a wide range of alkylation, acylation, and condensation reactions. This reactivity is fundamental to its use as a precursor for:

  • Pharmaceuticals: Including the synthesis of barbiturates, vitamins, and non-steroidal anti-inflammatory drugs.
  • Agrochemicals: Such as herbicides and pesticides.
  • Dyes and Pigments: Contributing to the production of various colored compounds.
  • Flavors and Fragrances: Due to its inherent pleasant aroma.

For businesses looking to buy Diethyl Malonate, selecting a reliable manufacturer is essential to ensure high purity (commonly 99.50% min) and consistent quality. As a leading supplier from China, NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing Diethyl Malonate that meets rigorous standards. Our efficient manufacturing processes and stringent quality control ensure that you receive a product suitable for even the most demanding synthesis applications.

We encourage professionals in the chemical, pharmaceutical, and agrochemical industries to consider our high-quality Diethyl Malonate. Inquire about pricing and availability to secure this vital intermediate for your research and production needs. Partnering with us means gaining access to a dependable source for your chemical raw materials.