The Chemistry Behind Peptide Synthesis: Focus on N-Cbz-Piperidine-2-carboxylic Acid
The field of peptide chemistry is fundamental to understanding biological functions and developing novel pharmaceuticals. At the heart of synthesizing these complex molecules lies the careful manipulation of amino acids, which often requires the use of protected derivatives. N-Cbz-Piperidine-2-carboxylic acid is a prime example of such a derivative, playing a significant role in enabling precise peptide synthesis. This article explores its chemical properties and its impact on advancements in drug discovery.
N-Cbz-Piperidine-2-carboxylic acid, identified by CAS number 71170-88-2, is a derivative of piperidine-2-carboxylic acid where the nitrogen atom is protected by a benzyloxycarbonyl (Cbz) group. This protection strategy is crucial in peptide synthesis for several reasons. The Cbz group offers robust protection for the secondary amine of the piperidine ring, preventing it from participating in unintended reactions during the assembly of the peptide chain. The piperidine ring itself, when incorporated into a peptide sequence, can impart specific conformational constraints or functional properties, making it a valuable component in designing peptides with targeted biological activities.
The synthesis of N-Cbz-Piperidine-2-carboxylic acid typically involves the reaction of piperidine-2-carboxylic acid with benzyl chloroformate under basic conditions. The resulting product is a white to off-white crystalline powder with a high purity, commonly specified at 98%. This level of purity is essential for researchers aiming to build complex peptides, as impurities can lead to erroneous sequences or reduced yields. The ability to reliably buy N-Cbz-Piperidine-2-carboxylic acid from reputable manufacturers, such as NINGBO INNO PHARMCHEM CO.,LTD, is therefore critical for the progress of many research projects.
In drug discovery, peptides are increasingly being explored for their therapeutic potential. N-Cbz-Piperidine-2-carboxylic acid serves as a versatile building block in creating peptidomimetics or modified peptides that exhibit enhanced stability, bioavailability, or receptor binding affinity. Its incorporation can introduce specific structural motifs that are key to the peptide's function. For professionals in chemical synthesis and pharmaceutical research, understanding the properties and reliable sourcing of such intermediates is paramount to achieving breakthroughs.
N-Cbz-Piperidine-2-carboxylic acid, identified by CAS number 71170-88-2, is a derivative of piperidine-2-carboxylic acid where the nitrogen atom is protected by a benzyloxycarbonyl (Cbz) group. This protection strategy is crucial in peptide synthesis for several reasons. The Cbz group offers robust protection for the secondary amine of the piperidine ring, preventing it from participating in unintended reactions during the assembly of the peptide chain. The piperidine ring itself, when incorporated into a peptide sequence, can impart specific conformational constraints or functional properties, making it a valuable component in designing peptides with targeted biological activities.
The synthesis of N-Cbz-Piperidine-2-carboxylic acid typically involves the reaction of piperidine-2-carboxylic acid with benzyl chloroformate under basic conditions. The resulting product is a white to off-white crystalline powder with a high purity, commonly specified at 98%. This level of purity is essential for researchers aiming to build complex peptides, as impurities can lead to erroneous sequences or reduced yields. The ability to reliably buy N-Cbz-Piperidine-2-carboxylic acid from reputable manufacturers, such as NINGBO INNO PHARMCHEM CO.,LTD, is therefore critical for the progress of many research projects.
In drug discovery, peptides are increasingly being explored for their therapeutic potential. N-Cbz-Piperidine-2-carboxylic acid serves as a versatile building block in creating peptidomimetics or modified peptides that exhibit enhanced stability, bioavailability, or receptor binding affinity. Its incorporation can introduce specific structural motifs that are key to the peptide's function. For professionals in chemical synthesis and pharmaceutical research, understanding the properties and reliable sourcing of such intermediates is paramount to achieving breakthroughs.
Perspectives & Insights
Molecule Vision 7
“N-Cbz-Piperidine-2-carboxylic acid, identified by CAS number 71170-88-2, is a derivative of piperidine-2-carboxylic acid where the nitrogen atom is protected by a benzyloxycarbonyl (Cbz) group.”
Alpha Origin 24
“The Cbz group offers robust protection for the secondary amine of the piperidine ring, preventing it from participating in unintended reactions during the assembly of the peptide chain.”
Future Analyst X
“The piperidine ring itself, when incorporated into a peptide sequence, can impart specific conformational constraints or functional properties, making it a valuable component in designing peptides with targeted biological activities.”