Understanding the fundamental chemistry of a compound is crucial for maximizing its utility in research and manufacturing. 2-Fluoro-3-iodopyridine (CAS 113975-22-7) is a valuable heterocyclic intermediate whose properties and synthesis pathways are of significant interest to chemists across various disciplines.

This compound is characterized by its molecular formula C5H3FIN and a molecular weight of 222.987. It typically appears as a white powder, with a melting point reported in the range of 45-46°C. The density is approximately 2.046 g/cm³, and it has a boiling point of 230.3°C at 760 mmHg. Its flash point is 93.1°C, indicating moderate flammability. Importantly, 2-Fluoro-3-iodopyridine is often supplied with a high purity of ≥99.0%, making it suitable for demanding synthetic applications where impurity control is paramount.

The synthesis of 2-Fluoro-3-iodopyridine commonly involves the directed ortho-metalation of 2-fluoropyridine using a strong base like Lithium Diisopropylamide (LDA) at low temperatures, followed by quenching with an iodine source. This method allows for regioselective introduction of the iodine atom at the 3-position. Optimization of reaction conditions, including temperature, solvent, and reaction time, is critical to achieving high yields and purity, minimizing the formation of unwanted isomers or by-products.

The applications of 2-Fluoro-3-iodopyridine are predominantly found in the synthesis of pharmaceutical intermediates and, to some extent, in agrochemical development. Its structure makes it an ideal starting material for creating complex molecules through various cross-coupling reactions. In medicinal chemistry, it serves as a key building block for developing novel therapeutic agents, particularly in areas such as oncology, neurology, and inflammatory diseases. The fluorine atom can enhance metabolic stability and bioavailability, while the iodine atom acts as a versatile handle for further derivatization.

For companies and research institutions requiring this compound, NINGBO INNO PHARMCHEM CO.,LTD. offers reliable access to high-quality 2-Fluoro-3-iodopyridine. We understand the importance of consistent purity and timely supply for our clients. We encourage you to contact us to inquire about our product specifications, current pricing, and bulk order capabilities. Partnering with a reputable manufacturer ensures you receive a dependable supply of this essential chemical intermediate, supporting your ongoing research and production needs efficiently.